{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T04:06:47Z","timestamp":1761624407987,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006692","name":"Universit\u00e0 degli Studi di Torino","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The incidence of both malignant melanoma (MM) and non\u2010Hodgkin lymphoma (NHL) has risen in recent decades, with studies suggesting a potential bidirectional association. Nonetheless, synchronous presentation of active disease in both entities remains rare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We report the case of a 62\u2010year\u2010old man with a history of indolent B\u2010cell lymphoma, exhibiting features between marginal zone and follicular subtype, previously treated with R\u2010CHOP, radiotherapy, and Rituximab maintenance, achieving complete remission. Ten years later, he developed an ulcerated superficial spreading melanoma (Breslow thickness 4.5\u2009mm, pT4b), with staging CT revealing right axillary lymphadenopathy. Biopsy confirmed relapsed follicular lymphoma. Surgical management included wide excision and sentinel lymph node biopsy, which identified melanoma metastasis in one sentinel node and confirmed FL in the non\u2010sentinel node. Molecular testing showed a BRAFV600E mutation. The patient received axillary radiotherapy followed by adjuvant BRAF\/MEK inhibitor therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>At 6\u2010month follow\u2010up, imaging showed no evidence of relapse. This represents the first documented case of synchronous stage III BRAF\u2010mutated MM and FL managed with targeted BRAF\/MEK inhibitors combined with localized radiotherapy. The successful outcome validates this sequential multidisciplinary approach and underscores the importance of dermatologic surveillance in NHL survivors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70363","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T08:32:52Z","timestamp":1760344372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Synchronous Melanoma and Follicular Lymphoma in the Same Nodal Basin: A Diagnostic and Therapeutic Challenge"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2591-5612","authenticated-orcid":false,"given":"Silvia","family":"Borriello","sequence":"first","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7728-6832","authenticated-orcid":false,"given":"Umberto","family":"Santaniello","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medical Sciences University of Turin  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo G.","family":"Brizio","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medical Sciences AOU Citt\u00e0 della Salute e della Scienza  Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8443-7458","authenticated-orcid":false,"given":"Paolo","family":"Fava","sequence":"additional","affiliation":[{"name":"Section of Dermatology and Venereology, Department of Medical Sciences AOU Citt\u00e0 della Salute e della Scienza  Turin 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