{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:11:43Z","timestamp":1766509903914,"version":"3.48.0"},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Daratumumab represents the first\u2010in\u2010class fully humanized monoclonal antibody that targets CD38 for the treatment of relapsed\/refractory multiple myeloma (RRMM). Evidence from randomized controlled trials has shown daratumumab to be efficacious in the setting of second\u2010line combinational therapy for pretreated multiple myeloma. However, real\u2010world evidence that supports daratumumab use in daily clinical practice remains scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The primary objective of this study was to describe the real\u2010world clinical and adverse effects observed in RRMM patients receiving daratumumab as second\u2010line therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was an observational case series with a retrospective chart review of pretreated multiple myeloma patients who received daratumumab\u2010based combinational therapy at an academic medical center. The primary end point was progression\u2010free survival. Additional end points included overall response rates, adverse effects of daratumumab therapy, and subsequent treatment options following daratumumab.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seventeen patients were included. The overall response rate of daratumumab in our patients with RRMM was 13\/17 (76.5%), and the median progression\u2010free survival was 20\u2009months when daratumumab was used in the second\u2010line setting. Common adverse effects included neutropenia (52.9%), thrombocytopenia (64.7%), anemia (35.7%), and pneumonia (35.3%). On follow\u2010up, 10 patients remained alive at the experimental cut\u2010off date, with 2 patients kept on daratumumab\u2010based combinational therapy; 5 patients were switched to carfilzomib\u2010based therapy; and 3 received best supportive care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In our single\u2010center experience with Taiwanese RRMM patients, daratumumab in combinational therapy showed promising efficacy, and modest tolerance in the second\u2010line setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70367","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T01:44:17Z","timestamp":1764467057000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Daratumumab\u2010Based Combinational Therapy as Second\u2010Line Treatment of Relapsed\u2010Refractory Multiple Myeloma: A Single\u2010Center Experience"],"prefix":"10.1002","volume":"8","author":[{"given":"Oscar C. Y.","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8170-8629","authenticated-orcid":false,"given":"Yi\u2010Hao","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Medicine MacKay Medical College  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caleb Gonshen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Medicine MacKay Medical College  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Cheng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"},{"name":"Department of Medicine MacKay Medical College  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming\u2010Chih","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huan\u2010Chau","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay Memorial Hospital  Taipei Taiwan"},{"name":"Department of Medical Research, Laboratory of Good Clinical Research Center MacKay Memorial Hospital  New Taipei City Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnson","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology and Oncology MacKay 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