{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:39:06Z","timestamp":1764056346883,"version":"3.45.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>With the increased rate of breast cancer affecting one in every nine women in Pakistan, breast cancer treatment, particularly chemotherapy, is often very challenging for patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aims to explore chemotherapy related\u2010challenges among females in Pakistan.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Semi\u2010structured, face\u2010to\u2010face interviews were conducted with 40 post\u2010chemotherapy females at the tertiary care setting in Islamabad, Pakistan, from February 2024 to April 2024, using a purposive sampling technique. Each 15\u201320\u2009min interview was audio recorded in the national language (Urdu), transcribed, and analyzed using a thematic analysis approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study included women with an average age of 47\u2009years; most were married (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200933), had primary education (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913), were unemployed (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935), and had a low family income (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936). Overall, participants reported hair loss (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935), darkened nails (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200926), mouth sores (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200924), weakness (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200921), vomiting (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200920), diarrhea (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200915), constipation (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913), and various other effects. Participants experienced significant physical challenges, psychological impact, economic strain, and informational challenges. However, coping strategies such as alternative treatments, staying motivated, managing side effects, and support from friends and family helped patients effectively deal with their chemotherapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight the need for financial support programs and government interventions to enhance the affordability of chemotherapy treatment. Furthermore, this study implies that healthcare professionals improve patient outcomes by counseling them about chemotherapy and its possible side effects before the treatment begins.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70381","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T16:11:39Z","timestamp":1763050299000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploring Challenges Related to Breast Cancer Chemotherapy Among Females in Pakistan: A Qualitative Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4500-6699","authenticated-orcid":false,"given":"Rehana","family":"Sarwat","sequence":"first","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6142-9430","authenticated-orcid":false,"given":"Muhammad Amir","family":"Hamza","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2228-7383","authenticated-orcid":false,"given":"Ayesha","family":"Azam","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4410-2628","authenticated-orcid":false,"given":"Bushra Batool","family":"Zahra","sequence":"additional","affiliation":[{"name":"Riphah Institute of Pharmaceutical Sciences Riphah International University  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7928-199X","authenticated-orcid":false,"given":"Muhammad","family":"Amer","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Abasyn University, Islamabad Campus  Islamabad Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1365-548X","authenticated-orcid":false,"given":"Zakir","family":"Khan","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Biomolecular Sciences RCSI University of Medicine and Health Sciences  Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5437-1988","authenticated-orcid":false,"given":"Maryam","family":"Mahmood","sequence":"additional","affiliation":[{"name":"Pharmacy Practice and Global Public Health, School of Health and Social Care University of Essex  Colchester Essex UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8964-1853","authenticated-orcid":false,"given":"Ali","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Global Public Health, School of Medicine University of California San Diego (UCSD)  La Jolla California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12207"},{"key":"e_1_2_14_3_1","unstructured":"World Health Organization \u201cBreast Cancer \u201d 2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/breast\u2010cancer."},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e16427"},{"issue":"4","key":"e_1_2_14_5_1","first-page":"586","article-title":"Breast Cancer Among Pakistani Women","volume":"44","author":"Menhas R.","year":"2015","journal-title":"Iranian Journal of Public Health"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S270671"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4137\/BCBCR.S29420"},{"volume-title":"Cancer Facts and Figures: 2019","year":"2019","author":"American Cancer Society","key":"e_1_2_14_8_1"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021695"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.19323"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155220915767"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nop2.1029"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cegh.2017.08.001"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40359-021-00515-8"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-024-03016-z"},{"key":"e_1_2_14_16_1","first-page":"1955","volume-title":"Patient Preference and Adherence","author":"Nies Y. H.","year":"2018"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2018.2011.00644.x"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2023.1537"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00329"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552241266254"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2020.100278"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-47674-4.00039-6"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/GME.0000000000001507"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-023-01954-6"},{"issue":"2","key":"e_1_2_14_25_1","first-page":"521","article-title":"Physical and Emotional Experiences of Chemotherapy: A Qualitative Study Among Women With Breast Cancer in Southern Thailand","volume":"19","author":"Suwankhong D.","year":"2018","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12912-023-01184-1"},{"issue":"1","key":"e_1_2_14_27_1","first-page":"116","article-title":"Psychological Effects of Chemotherapy Experienced by Patients Diagnosed With Breast and Cervical Cancer Attending Kenyatta National Hospital Cancer Treatment Centre","volume":"10","author":"Bosire A.","year":"2020","journal-title":"International Journal of Health Sciences and Research"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-022-07325-7"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2022.841963"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases4020017"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.4212\/cjhp.v68i3.1456"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzm042"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2021.745545"},{"key":"e_1_2_14_34_1","unstructured":"Pakistan Institute of Medical Sciences (PIMS) \u201cOverview \u201dhttps:\/\/pims.gov.pk\/about.php."},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2022.940514"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphs.12216"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/1525822X05279903"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11135-017-0574-8"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1191\/1478088706qp063oa"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.33314\/jnhrc.v17i4.1042"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/jan.13309"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.13.5305"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.03.019"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-012-1493-9"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1540415319837680"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29120746"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12913-022-08927-x"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12905-020-00909-7"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/heapro\/daaa091"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11764-010-0125-y"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931101)72:9<2612::AID-CNCR2820720916>3.0.CO;2-F"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980815)83:4<777::AID-CNCR22>3.0.CO;2-O"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi110"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0257680"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118993811.ch21"},{"volume-title":"Social Support: Theory, Research and Applications","year":"2013","author":"Sarason I. G.","key":"e_1_2_14_56_1"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781118524275.ejdj0066"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231691"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/10781552211017199"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/00469580251335819"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:37:00Z","timestamp":1764056220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cnr2.70381"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70381","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-04-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70381"}}