{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:11:40Z","timestamp":1766509900010,"version":"3.48.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objectives<\/jats:title>\n Penile squamous cell carcinoma (PSCC) is the most common penile cancer, accounting for \u2265\u200995% of cases, though it accounts for <\u20091% of all malignancies in men in the United States. We report an updated, stage\u2010stratified analysis of the efficacy of surgery, radiation, and chemotherapy, including adjuvant and neoadjuvant chemoradiation, with further analysis of demographic and clinical factors.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Using the Surveillance, Epidemiology, and End Results (SEER) database, patients with PSCC diagnosed between 2000 and 2018 were identified. Five\u2010year overall survival Cox regression analysis as well as univariate Kaplan\u2013Meier analysis were performed, stratified by demographic and treatment variables.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Two thousand seven hundred eight patients with PSCC were identified, with 57.8% being older than 65\u2009years at diagnosis and 94.2% undergoing surgical intervention. With multivariate analysis, increasing disease stage (\n p<\/jats:italic>\n \u2009<\u20090.001), age\u2009<\u200965\u2009years (\n p<\/jats:italic>\n \u2009<\u20090.001), lower disease grade (\n p<\/jats:italic>\n \u2009<\u20090.001) were all associated with increased survival, while treatment with chemotherapy or radiotherapy was both associated with decreased survival (\n p<\/jats:italic>\n \u2009=\u20090.002 and <\u20090.001, respectively). On univariate analysis, less invasive surgery was associated with increased survival among patients with low\u2010grade, local (\n p<\/jats:italic>\n \u2009<\u20090.001) or regional (\n p<\/jats:italic>\n \u2009=\u20090.03) disease. Among those with high\u2010grade disease, local excision was associated with increased survival (\n p<\/jats:italic>\n \u2009=\u20090.008), though among those with regional disease no survival difference was seen (\n p<\/jats:italic>\n \u2009=\u20090.86). Patients with regional disease saw increasing survival with four or more lymph nodes dissected (69% vs. 61%, respectively;\n p<\/jats:italic>\n \u2009=\u20090.002).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Surgical management of penile SCC remains the mainstay treatment, and less invasive surgery is associated with noninferior or improved 5\u2010year overall survival regardless of disease stage and grade. Patients with regional disease had increased survival when four or more lymph nodes were dissected. Future analysis of these trends stratified by disease subhistology and more granular analysis of the role of lymphadenectomy are warranted.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70383","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T20:38:33Z","timestamp":1764794313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demographics, Clinical Characteristics, and a Stage\u2010Based Analysis of Treatments and Outcomes for Squamous Cell Carcinoma of the Penis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0632-1865","authenticated-orcid":false,"given":"George M.","family":"Edwards","sequence":"first","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0343-8398","authenticated-orcid":false,"given":"Lucas W.","family":"Ashley","sequence":"additional","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Holmes","sequence":"additional","affiliation":[{"name":"Independent Researcher Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2904-8564","authenticated-orcid":false,"given":"Andrew W.","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arjun","family":"Bhatt","sequence":"additional","affiliation":[{"name":"Brody School of Medicine East Carolina University Greenville North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-8345","authenticated-orcid":false,"given":"Michael C.","family":"Larkins","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Boonshoft School of Medicine at Wright State University Fairborn Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20175009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21590"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2012.10.029"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"140","article-title":"Prognostic Factors in Squamous Cell Carcinoma of the Penis","volume":"4","author":"Novara G.","year":"2007","journal-title":"Nature Reviews. 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