{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:11:40Z","timestamp":1766509900005,"version":"3.48.0"},"reference-count":16,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T00:00:00Z","timestamp":1764288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Symptomatic bone marrow metastasis in squamous cell lung cancer after achieving a complete response to immunochemotherapy has not been reported previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation<\/jats:title>\n                    <jats:p>A 63\u2010year\u2010old Japanese man was referred to our hospital for further examination of an abnormal chest radiograph. Whole\u2010body computed tomography revealed left hilar swelling and osteolytic lesions. Bronchoscopic examination led to a diagnosis of squamous cell lung carcinoma with multiple bone metastases. He was treated with carboplatin\/Nab\u2010paclitaxel and pembrolizumab, and achieved complete response as determined by positron emission tomography with fluorodeoxyglucose\u2010computed tomography. Despite pembrolizumab maintenance therapy for 1\u2009year, thrombocytopenia, anemia, and leukoerythroblastosis occurred. Bone marrow biopsy revealed squamous cell carcinoma cells within fibrotic tissue, confirming the diagnosis of symptomatic bone marrow metastases. The patient died 1\u2009month after this diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Recurrence presenting bone marrow metastasis should be considered in patients with squamous cell lung cancer, even achieving complete response to immunochemotherapy, particularly those with bone metastases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70385","type":"journal-article","created":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T02:24:47Z","timestamp":1764383087000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development of Symptomatic Bone Marrow Metastasis After Complete Response to Immunochemotherapy in Squamous Cell Lung Carcinoma"],"prefix":"10.1002","volume":"8","author":[{"given":"Akari","family":"Momose","sequence":"first","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5182-0960","authenticated-orcid":false,"given":"Tomonobu","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"},{"name":"Shinshu Cancer Center, Shinshu University Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Takei","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaro","family":"Waki","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Midorikawa","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nami","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Hematology and Medical Oncology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Ohya","sequence":"additional","affiliation":[{"name":"Department of Pathology Shinshu University School of Medicine  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6531-7179","authenticated-orcid":false,"given":"Hideaki","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Medicine Nagano Prefectural Kiso Hospital  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-021-01418-9"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.172717"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/aam.aam_55_23"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-008-0503-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.1.61"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13918"},{"key":"e_1_2_10_8_1","first-page":"1","article-title":"Cytomorphological Evaluation of Non\u2010Haematopoietic Malignancies Metastasizing to the Bone Marrow","volume":"13","author":"Gajendra S.","year":"2023","journal-title":"American Journal of Blood Research"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1390361"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300891619839864"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jncc.2024.07.003"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.32677\/IJCR.2020.v06.i06.011"},{"key":"e_1_2_10_13_1","first-page":"121","article-title":"Squamous Cell Lung Cancer Presenting With Initial Rare Paraneoplastic Hematological Findings","volume":"57","author":"\u00c7ift\u00e7iler R.","year":"2024","journal-title":"Acta Haematologica Oncologica Turcica"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/9852632"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivv082"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13480"},{"key":"e_1_2_10_17_1","first-page":"85","article-title":"Crizotinib Treatment in a Lung Adenocarcinoma Harboring ALK Fusion Gene With Bone Marrow Metastasis: Case Report and Literature Review","volume":"18","author":"Li X.","year":"2015","journal-title":"Zhongguo Fei Ai Za Zhi"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:45:46Z","timestamp":1766508346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,28]]},"references-count":16,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/cnr2.70385"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70385","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"type":"print","value":"2573-8348"},{"type":"electronic","value":"2573-8348"}],"subject":[],"published":{"date-parts":[[2025,11,28]]},"assertion":[{"value":"2025-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70385"}}