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Despite advanced targeted therapies and precision medicine, therapeutic resistance continues to undermine durable clinical responses. Increasing evidence links epigenetic dysregulation and autophagy as central contributors to breast cancer progression, therapy resistance, and metabolic changes. Histone modifications, non\u2010coding RNAs, and DNA methylation dynamically regulate autophagy\u2010related genes (\n                      <jats:italic>ATGs<\/jats:italic>\n                      ), while autophagy itself co\u2010regulates the epigenetic landscape under chemotherapeutic stress. This two\u2010way interplay determines tumor cell fate, influencing sensitivity to chemotherapy, endocrine therapy, and targeted agents.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This article reviews recent studies on epigenetic mechanisms modulating autophagy and their impact on resistance pathways in breast cancer. Furthermore, this article highlighted the emerging role of epigenetic\u2010autophagy as a biomarker for early detection, disease monitoring, and predicting therapeutic response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Finally, the review outlined new therapeutic methods that combine epigenetic modulators and autophagy inhibitors with particular attention to AI\u2010driven drug discovery and precision oncology. Collectively, this review emphasizes the potential of targeting epigenetic\u2013autophagy crosstalk to overcome therapy resistance and improve patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70389","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T14:40:11Z","timestamp":1764686411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6813-9249","authenticated-orcid":false,"given":"Bushra","family":"Faryal","sequence":"first","affiliation":[{"name":"Department of Precision Medicine University of Campania \u201cLuigi Vanvitelli,\u201d  Naples 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