{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:01:58Z","timestamp":1785855718691,"version":"3.56.0"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2023YFC2705800"],"award-info":[{"award-number":["2023YFC2705800"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007219","name":"Natural Science Foundation of Shanghai Municipality","doi-asserted-by":"publisher","award":["25ZR1401033"],"award-info":[{"award-number":["25ZR1401033"]}],"id":[{"id":"10.13039\/100007219","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Non\u2010gestational choriocarcinoma (NGCC) is a rare type of malignant tumor. Primary lesions are typically detected in the ovary and rarely invade the corpus uteri and cervix. NGCC usually has a poor prognosis due to the difficulty in achieving early and accurate diagnoses because of its rarity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>This case described a female who was initially diagnosed with gestational choriocarcinoma and treated with EMA\u2010CO chemotherapy. However, subsequent short tandem repeat (STR) analysis confirmed the diagnosis as NGCC, prompting surgical intervention. Given her favorable response and after thorough communication, three additional cycles of EMA\u2010CO chemotherapy were recommended. At her last follow\u2010up, her human chorionic gonadotropin level had normalized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case presents a rare instance of NGCC with simultaneous uterine and cervical involvement, confirmed by STR analysis and successfully managed with the EMA\u2010CO regime. It highlights the necessity of precise diagnosis and personalized treatment for effective management of this disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70393","type":"journal-article","created":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T09:58:13Z","timestamp":1762423093000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Precision Diagnosis and Individualized Therapy of Non\u2010Gestational Choriocarcinoma Invading the Corpus Uteri and Cervix: A Case Report and Literature Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8580-6109","authenticated-orcid":false,"given":"Jiahui","family":"Ma","sequence":"first","affiliation":[{"name":"Clinical Research Unit Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-8058","authenticated-orcid":false,"given":"Fenghua","family":"Ma","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"},{"name":"Department of Radiology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7682-512X","authenticated-orcid":false,"given":"Tingting","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"},{"name":"Department of Pathology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8054-6940","authenticated-orcid":false,"given":"Xin","family":"Lu","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"},{"name":"Department of Gynecologic Oncology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5413-7836","authenticated-orcid":false,"given":"Yan","family":"Du","sequence":"additional","affiliation":[{"name":"Clinical Research Unit Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"},{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-9267-0981","authenticated-orcid":false,"given":"Xiaoni","family":"Yue","sequence":"additional","affiliation":[{"name":"Shanghai Key Lab of Reproduction and Development  Shanghai China"},{"name":"Shanghai Key Lab of Female Reproductive Endocrine Related Diseases  Shanghai China"},{"name":"Department of Gynecologic Oncology Obstetrics and Gynecology Hospital of Fudan University  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2022.12.020"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-020-01610-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.03.045"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000219386"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.2361"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e318241d556"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2014.04.013"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009899"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/pin.12763"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2019.1617564"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-246731"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-024-04664-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004906"},{"key":"e_1_2_11_15_1","article-title":"Non\u2010Gestational Choriocarcinoma of the Ovary: A Report of a Rare Case From Saudi Arabia","volume":"16","author":"Sait H. K.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2023-004704"},{"key":"e_1_2_11_17_1","first-page":"7049","article-title":"A Pilot Study Comparing the Genetic Molecular Biology of Gestational and Non\u2010Gestational Choriocarcinoma","volume":"11","author":"Lazare C.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2021.02.005"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00831-9"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2023.10.004"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.48095\/cccg2024396"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44411-025-00026-7"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T07:36:16Z","timestamp":1764056176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":21,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["10.1002\/cnr2.70393"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70393","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"2025-08-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70393"}}