{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:12:31Z","timestamp":1766509951559,"version":"3.48.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Cancer of unknown primary (\n                      <jats:styled-content style=\"fixed-case\">CUP<\/jats:styled-content>\n                      ) presents diagnostic and management challenges, particularly when associated with rare subsets such as pelvic squamous cell carcinoma (\n                      <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>\n                      ) of unknown primary origin. Human papillomavirus (HPV) is increasingly recognized as a prognostic and potentially predictive biomarker. HPV\u2010associated SCCs often demonstrate better response to treatment and improved outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Cases<\/jats:title>\n                    <jats:p>We present two cases of pelvic SCC with unknown primary origin, both positive for HPV genotype 16. Case 1 involved a 54\u2010year\u2010old woman with persistent abdominal pain who was diagnosed with an infiltrative 110\u2009\u00d7\u2009100\u2009\u00d7\u200965\u2009mm tumoral mass on the right side of the pelvic cavity, significantly involving the right iliac bone and right iliopsoas muscle; despite chemotherapy, the patient developed metastases. Case 2 featured a 46\u2010year\u2010old woman with progressive left lower limb pain, whose pelvic SCC was incidentally discovered on imaging with an 80\u2009\u00d7\u200975\u2009mm mass with an abnormal signal in the left iliac bone with extension to the left iliopsoas muscle involving the lower aspect of the iliopsoas muscle, and also involving the anterior aspect of the left sacral bone. She achieved a complete response to chemotherapy and chemoradiotherapy, with no evidence of recurrence during follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>HPV\u2010associated pelvic SCC of unknown primary presents both diagnostic complexity and therapeutic opportunity. The detection of HPV genotype 16 in both cases supports a growing body of case\u2010based evidence suggesting a potential association with a favorable prognosis. However, further studies are needed to clarify its role in guiding management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70402","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T02:26:17Z","timestamp":1764815177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>HPV<\/scp>\n                    \u2010Related Pelvic Squamous Cell Carcinoma of Unknown Primary: Two Case Studies"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-7334-0370","authenticated-orcid":false,"given":"Sepideh","family":"Soltani","sequence":"first","affiliation":[{"name":"Department Of Radiation Oncology, School of Medicine Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahar","family":"Dashti","sequence":"additional","affiliation":[{"name":"Department Of Radiation Oncology, School 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