{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:12:27Z","timestamp":1766509947811,"version":"3.48.0"},"reference-count":63,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T00:00:00Z","timestamp":1764374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Evidence indicates that beta\u20102 microglobulin (\u03b22M) plays a prognostic role in patients with diffuse large B\u2010cell lymphoma (DLBCL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>However, due to controversies among previous studies, this meta\u2010analysis was conducted to evaluate the prognostic role of \u03b22M in DLBCL patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Relevant studies were identified through a systematic search using specific keywords in PubMed\/Medline, Scopus, and Web of Science databases. Studies that provided complete information on the hazard ratio with a 95% confidence interval for \u03b22M with respect to overall survival (OS) and progression\u2010free survival (PFS) in multivariate models were included in the meta\u2010analysis. A total of 30 studies, encompassing 25\u2009128 patients, were included in this meta\u2010analysis. The pooled analysis demonstrated a significant association between elevated \u03b22M levels and poor OS in DLBCL patients (HR\n                      <jats:sub>Pooled<\/jats:sub>\n                      : 1.65, 95% CI: 1.45\u20131.88,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.01). Similarly, increased \u03b22M levels were significantly associated with lower PFS in DLBCL patients (HR\n                      <jats:sub>Pooled<\/jats:sub>\n                      : 1.54, 95% CI: 1.39\u20131.70,\n                      <jats:italic>p<\/jats:italic>\n                      \u2010value\u2009&lt;\u20090.01).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The available evidence suggests that \u03b22M serves as an independent prognostic marker with significant effects on OS and PFS in DLBCL patients. Elevated serum \u03b22M levels are associated with poor prognosis and worse OS and PFS outcomes in DLBCL patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70416","type":"journal-article","created":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T01:28:39Z","timestamp":1764466119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Role of Beta\u20102 Microglobulin in Diffuse Large B\u2010Cell Lymphoma: Systematic Review and Meta\u2010Analysis of Observational Studies"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4554-9008","authenticated-orcid":false,"given":"Hamideh Feiz","family":"Disfani","sequence":"first","affiliation":[{"name":"Department of Emergency Medicine School of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8362-979X","authenticated-orcid":false,"given":"Mahsan","family":"Ramezani","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine School of Medicine, Neyshabur University of Medical Sciences  Neyshabur Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9060-0688","authenticated-orcid":false,"given":"Milad","family":"Moradi","sequence":"additional","affiliation":[{"name":"Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences  Kermanshah Iran"},{"name":"Department of Medical Physics School of Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4030-3850","authenticated-orcid":false,"given":"Mostafa","family":"Kamandi","sequence":"additional","affiliation":[{"name":"Hematologist\u2010Oncologist, Department of Internal Medicine Faculty of Medicine, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5476-4001","authenticated-orcid":false,"given":"Molood","family":"Foogerdi","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine Faculty of Medicine, Birgand University of Medical Sciences  Birjand Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0806-2559","authenticated-orcid":false,"given":"Vajiheh Sadat","family":"Saghi","sequence":"additional","affiliation":[{"name":"Torbat\u2010e Jam University of Medical Sciences  Torbat\u2010e Jam Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4171-6294","authenticated-orcid":false,"given":"Rasoul","family":"Shavaleh","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6940-7947","authenticated-orcid":false,"given":"Kazem","family":"Rahmani","sequence":"additional","affiliation":[{"name":"Department of Epidemiology School of Public Health, Iran University of Medical Sciences  Tehran Iran"},{"name":"Non\u2010Communicable Disease Center, Torbat\u2010e Jam University of Medical Sciences  Torbat\u2010e Jam Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,11,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1746-1596-6-77"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25460"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021013998"},{"issue":"1","key":"e_1_2_11_6_1","first-page":"51","article-title":"Current Frontline Treatment of Diffuse Large B\u2010Cell Lymphoma","volume":"36","author":"Spinner M. 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