{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T17:11:29Z","timestamp":1766509889597,"version":"3.48.0"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T00:00:00Z","timestamp":1766448000000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The retrospective data analysis on 80 patients from 2018 to 2022 aimed to determine the incidence and clinical outcomes of vitamin D status and myeloma bone disease among newly diagnosed multiple myeloma (MM) patients in Singapore.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Patients' demographics, bone health data and bone disease management were collected. Chi\u2010square test was conducted to compare variables between patients who survived versus those who demised. Survival differences were compared using log\u2010rank analysis and plotted using Kaplan\u2013Meier estimates. Multivariable survival analysis was conducted using Cox Regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifty\u2010nine (73.8%) patients had myeloma bone disease at diagnosis, and 42 (71.2%) of these patients had skeletal\u2010related adverse events at diagnosis. The compliance to bone health management needs to be optimized, as only 70 patients had their vitamin D level tested at diagnosis, of which 48 (68.7%) patients were vitamin D insufficient or deficient. Bone disease data did not correlate with mortality. Higher mortality was initially observed among patients with non\u2010Chinese (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.03), R\u2010ISS 3 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and renal involvement at diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.035). R\u2010ISS staging remained the only statistically significant variable after adjusting for race (adjusted HR 3.99; 95% CI 1.58\u201310.07).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The study found no correlation between myeloma bone health data and survival outcomes in our centre.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70431","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T12:43:52Z","timestamp":1766493832000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Incidence and Clinical Outcomes of Vitamin D Status and Myeloma Bone Disease Among Patients With Newly Diagnosed Multiple Myeloma (\n                    <scp>MM<\/scp>\n                    ) in a Tropical Country\u2014Retrospective Cohort Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5447-5092","authenticated-orcid":false,"given":"Chi Ching","family":"Lim","sequence":"first","affiliation":[{"name":"Division of Oncology Nursing National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai San Wilson","family":"Tam","sequence":"additional","affiliation":[{"name":"National University Health System  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8881-3537","authenticated-orcid":false,"given":"Widanalage Sanjay Prasad","family":"De Mel","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew Ping","family":"Lang","sequence":"additional","affiliation":[{"name":"Division of Oncology Nursing National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Joo","family":"Chng","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8376-8872","authenticated-orcid":false,"given":"Cinnie Yentia","family":"Soekojo","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5102-1418","authenticated-orcid":false,"given":"Fang Fang","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa Gaik Ming","family":"Ooi","sequence":"additional","affiliation":[{"name":"Department of Haematology\u2010Oncology National University Cancer Institute, Singapore  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.11622\/smedj.2016150"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102018\u201011\u2010852459"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25791"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.15406\/htij.2017.05.00112"},{"issue":"7","key":"e_1_2_13_6_1","doi-asserted-by":"crossref","DOI":"10.1177\/0300060520943421","article-title":"Vitamin D Levels in Patients With Non\u2010Hodgkin Lymphoma\/Diffuse Large B\u2010Cell Lymphoma, Chronic Lymphocytic Leukemia and 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