{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:51:04Z","timestamp":1791910264610,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Adenoid cystic carcinoma (ACC) of the breast is a special subtype of breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to systematically characterize the clinicopathologic features, treatment patterns, and prognostic indicators of breast ACC, with the overarching goal of enhancing clinical understanding and optimizing management strategies for this rare malignancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We conducted a retrospective investigation of 22 patients with breast ACC treated at The West China Hospital of Sichuan University between March 2009 and January 2021. Clinical manifestations, therapy strategies, pathological characteristics, and follow\u2010up information were systematically observed and analyzed. This study retrospectively analyzed 22 female patients with breast ACC, with ages ranging from 31 to 75\u2009years. Notably, 54.5% (12\/22) of the patients were postmenopausal. A palpable breast mass was the most common initial presenting symptom, observed in 95.5% (21\/22) of cases. In terms of molecular subtype, triple\u2010negative breast cancer (TNBC) was identified in 77.3% (17\/22) of patients. Conversely, the remaining 22.7% (5\/22) of cases showed positive expression for estrogen receptor (ER), progesterone receptor (PR), or human epidermal growth factor receptor 2 (HER2). All patients received surgical treatment, which included simple mastectomy, breast\u2010conserving surgery (BCS), or modified radical mastectomy. The surgical procedures were optionally accompanied by axillary lymph node dissection (ALND) or sentinel lymph node biopsy (SLNB). The majority of patients, 90.9% (20\/22), were diagnosed at early stages (Stage I or II), while only 2 patients were in Stage III. For postoperative adjuvant therapy, 6 patients underwent radiotherapy, 16 received chemotherapy, 2 received hormonal modulation, and 1 advanced\u2010stage patient participated in a clinical trial with bevacizumab therapy. During the follow\u2010up period, 4 patients (19%) developed distant metastasis. The 5\u2010year disease\u2010free survival rate was 95.4%, with 21 out of 22 patients remaining free from disease recurrence. Remarkably, all patients survived until the end of the last follow\u2010up, suggesting a relatively good prognosis for breast ACC in this cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Breast ACC is a rare type of TNBC that reportedly has indolent biologic behavior. Definitive preoperative diagnosis remains challenging using imaging modalities alone, as conclusive identification relies heavily on histopathological and immunohistochemical examinations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70442","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T06:45:33Z","timestamp":1768459533000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Adenoid Cystic Carcinoma of the Breast: Clinicopathological Features, Therapy Strategy, and Prognosis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-8157","authenticated-orcid":false,"given":"Lan","family":"Chen","sequence":"first","affiliation":[{"name":"Fushun People's Hospital  ZiGong Sichuan People's Republic of China"},{"name":"Department of Medical Oncology West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0588-4015","authenticated-orcid":false,"given":"Xi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Head and Neck Cancer Department West China Hospital, Sichuan University  Chengdu Sichuan People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr2613"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.04.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clbc.2012.09.002"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2010.12.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13005-020-00226-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.732"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2009.073908"},{"issue":"1","key":"e_1_2_12_9_1","first-page":"e8","article-title":"Adenoid Cystic Carcinoma of the Breast","volume":"50","author":"Law Y. 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