{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:08:53Z","timestamp":1769558933395,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["T32AR059033\u201012"],"award-info":[{"award-number":["T32AR059033\u201012"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Soft tissue sarcomas (STS) of the upper extremity (UE) are uncommon and may require complex surgical management. Socioeconomic disadvantage, race\/ethnicity, sex, and marital status may influence presentation, surgical complexity, local recurrence (LR), and overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The aim of this work is to examine the influence of socioeconomic and demographic factors on the presentation and outcomes of upper extremity soft tissue sarcomas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We identified patients treated surgically for primary UE STS (2012\u20102022). Demographics, tumor characteristics, and outcomes were recorded. Associations between demographics and time to presentation, skin grafting, amputation, and LR were assessed using chi\u2010square and\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests. Competing risks regression analyzed 3\u2010 and 5\u2010year LR, and Kaplan\u2010Meier analysis assessed 5\u2010year OS. Among 181 patients, the mean time to presentation was 17.1 months (SD 34.3), mean tumor size was 7.8 cm (SD 5.7) while 56% required re\u2010excision, 15% underwent amputation, 15% required skin grafting, and 24% experienced LR. Hispanic\/Latino patients presented with larger tumor sizes (9.17\u2009\u00b1\u20095.71 cm vs. 7.43\u2009\u00b1\u20095.61 cm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Non\u2010married patients had higher odds of amputation (OR 3.15,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012), and female sex predicted greater LR risk (OR 2.17,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037). Twenty\u2010one patients (11.1%) died within five years. In multivariable analysis, increasing tumor size (OR\u2009=\u20091.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) and high tumor grade (OR\u2009=\u20098.28;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.038) significantly impacted 5\u2010year OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>While disparities across patient demographics may exist for surgical outcomes for UE STS, racial disparities in overall survival may be mitigated with treatment at an urban, tertiary care sarcoma center.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70445","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:56:27Z","timestamp":1768398987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["How Do Patient Demographics and Socioeconomic Disadvantage Impact Clinical Presentation, Surgical Outcomes, and Survival for Upper Extremity Soft Tissue Sarcoma?"],"prefix":"10.1002","volume":"9","author":[{"given":"Nicole J.","family":"Newman\u2010Hung","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3164-6133","authenticated-orcid":false,"given":"Kameel","family":"Khabaz","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michaela","family":"Juels","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Gamalong","sequence":"additional","affiliation":[{"name":"David Geffen School of Medicine, University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Chiou","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bailey","family":"Mooney","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Harbor\u2010UCLA Medical Center  Torrence California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas M.","family":"Bernthal","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren E.","family":"Wessel","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery University of California  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,14]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"C. 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