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The\n                      <jats:italic>WRAP53<\/jats:italic>\n                      gene, which is associated with genomic stability due to its involvement in activities, such as DNA repair, TP53 regulation, and association with telomerase (hTERT), was the focus of this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to identify new potential molecular markers with prognostic value, based on specific targets, in order to contribute to a more accurate stratification of patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We assessed\n                      <jats:italic>WRAP53<\/jats:italic>\n                      and\n                      <jats:italic>hTERT<\/jats:italic>\n                      expression in 110 AML patients classified according to World Health Organization (WHO) guidelines. Using real\u2010time quantitative PCR, we investigated their expression and correlation with clinical outcome variables.\n                      <jats:italic>WRAP53<\/jats:italic>\n                      expression was significantly decreased in AML patients compared to controls, whereas we did not detect differences in\n                      <jats:italic>hTERT<\/jats:italic>\n                      expression. Correlation analysis revealed a moderate positive relationship between\n                      <jats:italic>WRAP53<\/jats:italic>\n                      and\n                      <jats:italic>hTERT<\/jats:italic>\n                      expression. Concerning the clinical parameters analyzed, significant differences were observed for\n                      <jats:italic>WRAP53<\/jats:italic>\n                      in terms of sex and age, whereas for\n                      <jats:italic>hTERT<\/jats:italic>\n                      , no differences in the parameters analyzed were observed. Overall survival analysis did not reveal a significant difference for either\n                      <jats:italic>WRAP53<\/jats:italic>\n                      or\n                      <jats:italic>hTERT<\/jats:italic>\n                      . The results presented demonstrate a downregulation of\n                      <jats:italic>WRAP53<\/jats:italic>\n                      in the studied sample and that, furthermore, the expression of the\n                      <jats:italic>WRAP53<\/jats:italic>\n                      and\n                      <jats:italic>hTERT<\/jats:italic>\n                      genes was correlated. In addition, the expression of\n                      <jats:italic>hTERT<\/jats:italic>\n                      , which is already indicated as a biomarker in AML, could not be correlated with the clinical characteristics analyzed in this study.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We also suggest that the low expression of\n                      <jats:italic>WRAP53<\/jats:italic>\n                      may be associated with other mechanisms in AML, such as DNA repair, thus becoming a possible new promising molecular biomarker related to genomic stability in AML.\n                    <\/jats:p>\n                  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