{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:09:55Z","timestamp":1772996995992,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T00:00:00Z","timestamp":1771372800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ewing sarcoma is a rare primary mesenchymal tumor of the bone that requires an intensive multimodal therapeutic approach. Multidrug chemotherapy regimens are also the backbone for relapsing\/recurring Ewing sarcoma treatment, yet when the disease relapses as bone marrow infiltration, combination chemotherapy might be difficult to administer and prognosis is poor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>This report describes the case of a 22\u2010year\u2010old patient with Ewing sarcoma who developed severe pancytopenia due to bone marrow infiltration, and who was treated with high\u2010dose continuous infusion ifosfamide, obtaining both clinical, radiological, and hematological response lasting for about 7\u2009months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>To our knowledge, this is the first described case of a patient with bone marrow infiltration from Ewing sarcoma presenting with severe thrombocytopenia successfully managed with low\u2010dose continuous infusion ifosfamide, providing almost 7\u2009months of progression\u2010free survival. Considering the very dismal prognosis of Ewing sarcoma relapsing with bone marrow infiltration, this case might be of help when decision\u2010making is required in this setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70468","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T08:24:58Z","timestamp":1771403098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["High\u2010Dose Continuous Infusion Ifosfamide as Effective Palliation in a Patient With Relapsed Ewing Sarcoma With Bone Marrow Infiltration and Severe Thrombocytopenia: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7617-916X","authenticated-orcid":false,"given":"Fabio","family":"Murtas","sequence":"first","affiliation":[{"name":"Oncology 1 Unit, Department of Oncology Istituto Oncologico Veneto IOV \u2013 IRCCS  Padua Italy"},{"name":"Department of 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Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Burei","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Veneto Institute of Oncology IOV\u2010IRCCS  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Coppola","sequence":"additional","affiliation":[{"name":"Pharmacy Veneto Institute of Oncology IOV\u2010 IRCCS  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Galiano","sequence":"additional","affiliation":[{"name":"Oncology 1 Unit, Department of Oncology Istituto Oncologico Veneto IOV \u2013 IRCCS  Padua Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maital","family":"Bolshinsky","sequence":"additional","affiliation":[{"name":"Oncology 1 Unit, Department of Oncology Istituto Oncologico Veneto IOV \u2013 IRCCS  Padua 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