{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:10:00Z","timestamp":1772997000928,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T00:00:00Z","timestamp":1769990400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82570134"],"award-info":[{"award-number":["82570134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2025A1515012002"],"award-info":[{"award-number":["2025A1515012002"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary mediastinal malignant melanoma (PMMM) presenting with pleural effusion as the initial manifestation is exceedingly rare, presenting significant diagnostic and therapeutic challenges. This article reports a case of PMMM that initially manifested as pleural effusion and includes a review of the relevant literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>The patient was admitted with pleural effusion and an anterior mediastinal mass. A pleural biopsy and fine\u2010needle aspiration of the mediastinal mass led to a pathological diagnosis of malignant melanoma. Ultimately, based on clinical findings, a final diagnosis of PMMM was established. The patient subsequently developed pleural hemorrhage; although hemostasis was achieved through thoracoscopy, his condition stabilized only temporarily. He ultimately succumbed to lung infection and multiple organ failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMMM presenting with pleural effusion lacks distinct clinical features, highlighting the importance of pathological diagnosis. Pleural hemorrhage associated with pleural metastasis may be a characteristic feature, and the prognosis for such cases is poor. Enhanced recognition and early intervention are essential to improve outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70484","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T03:26:24Z","timestamp":1770089184000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Primary Mediastinal Malignant Melanoma Presenting With Pleural Effusion: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"given":"Minlian","family":"Nong","sequence":"first","affiliation":[{"name":"Department of Geriatrics Respiratory Medicine The First Affiliated Hospital of Guangxi Medical University  Nanning People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weifeng","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital Guangzhou Medical University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naijian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital Guangzhou Medical University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxiang","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital Guangzhou Medical University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0525-6649","authenticated-orcid":false,"given":"Jinlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Disease, National Center for Respiratory Medicine, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital Guangzhou Medical University  Guangzhou People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2022.40.16_suppl.e21599"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000959"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-006-0004-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2012.13.6.823"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000006436"},{"issue":"1","key":"e_1_2_9_7_1","first-page":"E133","article-title":"A Primary Malignant Melanoma of the Mediastinum With Gross Surgical View","volume":"8","author":"Youn H. 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