{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:22:46Z","timestamp":1774502566048,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260462"],"award-info":[{"award-number":["82260462"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82460606"],"award-info":[{"award-number":["82460606"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Postsurgical immunotherapy for patients with locally advanced head and neck squamous cell carcinoma (HNSCC) remains elusive. This study assesses the value and significance of postoperative immunotherapy in the treatment of locally advanced HNSCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In total, 212 patients with locally advanced HNSCC who underwent radical surgery were stratified into three treatment groups: adjuvant radiotherapy alone, adjuvant chemoradiotherapy (CRT), and adjuvant chemoradiotherapy plus immunotherapy (PD\u20101 Ab). A comprehensive analysis was conducted to assess survival outcomes and prognostic factors across diverse patient cohorts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Four patients were lost to follow\u2010up, with a follow\u2010up rate of 98.1% and a median follow\u2010up time of 41\u2009months (IQR 24\u201368). A total of 64\/212 individuals died, with cancer being the cause of 62 cases and noncancer causes accounting for the remaining two deaths; 62\/212 (29.2%) patients experienced relapse and\/or metastasis. The 3\u2010year OS rates for the radiotherapy group, CRT group, and CRT plus PD\u20101 Ab group were 54.8%, 75.4%, and 82.2%, respectively. However, no statistically significant difference in OS or PFS was observed between the CRT and CRT\u2009+\u2009PD\u20101 Ab groups (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      &gt;\u20090.05), although both were superior to radiotherapy alone (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      &lt;\u20090.05). Multivariate analysis indicated that age, smoking history, TNM stage and treatment method were independent prognostic factors for OS (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      &lt;\u20090.05). Smoking history and treatment methods were independent prognostic factors for PFS and DMFS (\n                      <jats:italic>p<\/jats:italic>\n                      <jats:sub>all<\/jats:sub>\n                      &lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PD\u20101 Ab may contribute less to tumors with better treatment outcomes from concurrent chemoradiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70488","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:03:37Z","timestamp":1773029017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Postoperative Adjuvant Chemoradiotherapy\u2009\u00b1\u2009\n                    <scp>PD<\/scp>\n                    \u20101 Inhibitor for Locally Advanced Head and Neck Squamous Cell Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-320X","authenticated-orcid":false,"given":"Zhiqiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Radiotherapy Oncology First Affiliated Hospital of Kunming Medical University  Kunming People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-6974-4414","authenticated-orcid":false,"given":"Qingqing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Oncology First Affiliated Hospital of Kunming Medical University  Kunming People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7610-5666","authenticated-orcid":false,"given":"Donghui","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of 2nd Otorhinolaryngology The First Affiliated Hospital of 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