{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:19:47Z","timestamp":1774502387790,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T00:00:00Z","timestamp":1772755200000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Congenital dysfibrinogenemia (CD), a rare autosomal dominant coagulation disorder, poses significant perioperative challenges in oncologic surgery due to hypofibrinogenemia and variable bleeding\u2010thrombosis risks.<\/jats:p>\n <\/jats:sec>\n \n Case<\/jats:title>\n A 67\u2010year\u2010old woman presented with a 2.9\u2009\u00d7\u20091.4\u2009cm spiculated mass in the right middle lobe (RML) and persistent hypofibrinogenemia (0.56\u20130.58\u2009g\/L). Despite conventional fresh frozen plasma and cryoprecipitate transfusions, fibrinogen levels remained critically low. Preoperative optimization with human fibrinogen concentrates (total 4.0\u2009g) normalized levels to 1.76\u2009g\/L within 24\u2009h, enabling video\u2010assisted thoracoscopic (VATS) RML lobectomy with systematic lymphadenectomy (pT1cN0M0, Stage IA3). Postoperatively, fibrinogen gradually declined to 0.68\u2009g\/L at 1\u2010month follow\u2010up, necessitating extended surveillance. Genetic testing identified a heterozygous FGA c.103C>T (Arg35Cys) mutation, confirming CD diagnosis and thrombotic risk.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case establishes three paradigms: (1) Mandatory comprehensive coagulation profiling in pulmonary resection candidates to identify CD; (2) superiority of fibrinogen concentrate over plasma\u2010derived products for rapid, sustained hemostasis in CD; (3) individualized thromboprophylaxis balancing hemorrhagic\u2010thrombotic risks through genetic risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70512","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:24:18Z","timestamp":1772979858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Report: Co\u2010Occurrence of Lung Adenocarcinoma and Congenital Dysfibrinogenemia\u2014Diagnostic and Perioperative Management Challenges"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2284-2758","authenticated-orcid":false,"given":"He","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Suining First People's Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7102-7137","authenticated-orcid":false,"given":"Qingsong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Suining First People's Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0192-4914","authenticated-orcid":false,"given":"Mingpu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Suining First People's Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0863-9154","authenticated-orcid":false,"given":"Shu","family":"Luo","sequence":"additional","affiliation":[{"name":"Oncology Suining First People's Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8418-8144","authenticated-orcid":false,"given":"Yuzhen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery Suining First People's Hospital Suining Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-1348","authenticated-orcid":false,"given":"Zhengqiang","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Suining First People's Hospital Suining Sichuan 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\u201cStudy on Lymph Node Metastasis Patterns in Peripheral Lung Adenocarcinoma With Diameter \u22642cm \u201d Dalian Medical University 2023."},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2004.00944.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH10-03-0161"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14216"},{"key":"e_1_2_11_17_1","unstructured":"M.Luo \u201cIdentification of FGA Gene and Study on Molecular Pathogenic Mechanisms in Hereditary Dysfibrinogenemia \u201d Guangxi Medical University 2017."},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020010116"}],"container-title":["Cancer 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