{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T05:20:54Z","timestamp":1774502454546,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T00:00:00Z","timestamp":1772928000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>PRRX1<\/jats:italic>\n                      \u2010rearranged mesenchymal neoplasms are rare soft tissue tumors with a predilection for the superficial subcutaneous tissue. The\n                      <jats:italic>PRRX1::KMT2D<\/jats:italic>\n                      fusion variant is exceptionally rare, with only three previously reported cases, all of which were located in the intermuscular regions. However, its occurrence in deep visceral sites has not been documented.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>\n                      A 62\u2010year\u2010old woman was admitted after a routine physical examination revealed a space\u2010occupying lesion in the left thoracic cavity. Contrast\u2010enhanced CT showed a mixed\u2010density mass (10.4\u2009\u00d7\u20098.1\u2009\u00d7\u20093.8\u2009cm) at the left cardiophrenic angle. The patient underwent complete thoracoscopic resection. Intraoperative frozen sections suggested a spindle cell tumor. Postoperative pathology, immunohistochemistry, and targeted RNA sequencing identified a\n                      <jats:italic>PRRX1::KMT2D<\/jats:italic>\n                      fusion mesenchymal neoplasm. At 18\u2010month follow\u2010up, no recurrence or progression was observed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This is the first reported case of a\n                      <jats:italic>PRRX1::KMT2D<\/jats:italic>\n                      fusion mesenchymal neoplasm arising in the mediastinum, which expands the anatomical spectrum of this emerging entity. Our findings underscore the importance of integrating morphological, immunohistochemical, and molecular approaches for accurate diagnosis, particularly in deep\u2010seated and unusual locations.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70516","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:44:10Z","timestamp":1772988250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Expanding the Anatomical Distribution of\n                    <i>PRRX1::KMT2D<\/i>\n                    Fusion Mesenchymal Neoplasms: A Rare Mediastinal Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5493-893X","authenticated-orcid":false,"given":"Weixiang","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7513-1297","authenticated-orcid":false,"given":"Yu","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3789-3143","authenticated-orcid":false,"given":"Ke","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.22762"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/pas.0000000000001423"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010023\u201003575\u2010w"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn112151\u201020250124\u201000063"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969241311492"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428\u2010021\u201003219\u2010x"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13926"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379\u2010020\u20100582\u20104"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14683"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.14454"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14262"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp\u20102023\u2010209267"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00008193"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2024053872"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.06.056"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2022.11.015"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70516","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70516","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T03:25:31Z","timestamp":1774495531000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/cnr2.70516"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70516","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"2025-10-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70516"}}