{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:06:14Z","timestamp":1789563974366,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T00:00:00Z","timestamp":1775520000000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Terminalia macroptera<\/jats:italic>\n                      (Combretaceae) is an important medicinal plant in the traditional pharmacopeia in most tropical areas, where its different parts are used in treating illnesses including cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      In this study, two oleanane\u2010type triterpenoids: terminolic acid (TM32) and arjungenin (TM34), together with three saponins: arjunglucoside I (TM35), 24\u2010deoxysericoside (TM36) and chebuloside II (TM37) from\n                      <jats:italic>T. macroptera<\/jats:italic>\n                      , were screened for their cytotoxic effects against breast cancer cell lines.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      The compounds were isolated using column chromatography and characterized from their NMR data. Their cytotoxic and antiproliferative effects against estrogen non\u2010sensitive (MDA\u2010MB 231) and estrogen sensitive (MCF\u20107) breast cancer cell lines were evaluated. Against estrogen non\u2010sensitive (MDA\u2010MB 231) cancer cell lines, deoxysericoside (TM36) was profoundly active compared to the control. Terminolic acid (TM32), arjungenin (TM34), and arjunglucoside I (TM35) were also active. Against estrogen sensitive (MCF\u20107) breast cancer cell lines, deoxysericoside (TM36) exhibited significant activity (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) compared to control experiments. The most active compound had an optimum concentration of 30\u2009\u03bcg\/mL. Deoxysericoside (TM36) showed concentration\u2010dependent inhibition percentages at 15 and 30\u2009\u03bcg\/mL, and MDA\u2010MB 231 breast carcinoma cells were more susceptible. MDA\u2010MB 231 treated with 15 and 30\u2009\u03bcg\/mL of deoxysericoside (TM36) showed significant reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05) in clone formation after 48\u2009h when compared to untreated controls, suggesting that it can restrict cancer to a preliminary stage. The deoxysericoside (TM36) reduced cell migration with dose\u2010dependent improvement in wound healing at 15 and 30\u2009\u03bcg\/mL, revealed by the micrographs. Molecular docking indicated that the compounds fit well into hER\u03b1 and PI3K\u03b1 receptor binding sites, forming stable complexes with binding energies in ranges of \u22129.04 to \u22125.02\u2009kcal\u2009mol\n                      <jats:sup>\u22121<\/jats:sup>\n                      (hER\u03b1 receptor) and \u22128.84 to \u22125.97\u2009kcal\u2009mol\n                      <jats:sup>\u22121<\/jats:sup>\n                      (PI3K\u03b1 receptor). The compounds exhibited appreciable drug likeness predicted using SwissADME.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The studies showed that the isolated compounds could be used for the development of anticancer therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70541","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T03:05:26Z","timestamp":1775617526000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antiproliferative Effect of 24\u2010Deoxysericoside From\n                    <scp>\n                      <i>Terminalia macroptera<\/i>\n                    <\/scp>\n                    Guill. &amp; Perr. (Combretaceae) Against Breast Carcinoma: In\u00a0Vitro, Molecular Docking and\n                    <scp>ADME<\/scp>\n                    Assessment"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8690-9660","authenticated-orcid":false,"given":"Romeo Toko","family":"Feunaing","sequence":"first","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6683-3337","authenticated-orcid":false,"given":"Alfred Ngenge","family":"Tamfu","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, School of Chemical Engineering and Mineral Industries University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4666-2627","authenticated-orcid":false,"given":"Abel Joel Yaya","family":"Gbaweng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0183-1043","authenticated-orcid":false,"given":"Cyrille Leonel Tchuente","family":"Djoko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4145-4095","authenticated-orcid":false,"given":"Emmanuel","family":"Talla","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Sciences University of Ngaoundere  Ngaoundere Cameroon"},{"name":"Department of Materials Engineering, School of Chemical Engineering and Mineral Industries University of Ngaoundere  Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9240-7163","authenticated-orcid":false,"given":"El Hassane","family":"Anouar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Sciences and Humanities in Al\u2010Kharj Prince Sattam bin Abdulaziz University  Al\u2010Kharj Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-8783","authenticated-orcid":false,"given":"Stephane","family":"Zingue","sequence":"additional","affiliation":[{"name":"Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences University of Yaounde 1  Yaounde 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