{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:06:12Z","timestamp":1789563972797,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23K07609"],"award-info":[{"award-number":["23K07609"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      Transformation to small cell carcinoma, squamous cell carcinoma, and rarely, pleomorphic carcinoma (PC) has been reported to be found in\n                      <jats:italic>EGFR<\/jats:italic>\n                      \u2010mutated lung cancer with acquired resistance to EGFR tyrosine kinase inhibitors (TKIs). However, evidence for underlying factors including genomic profiles associated with PC transformation has been lacking.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>\n                      We report a case of\n                      <jats:italic>EGFR<\/jats:italic>\n                      \u2010mutated lung adenocarcinoma that transformed to PC confirmed by an autopsy after stereotactic radiotherapy and treatment with EGFR\u2010TKIs. Comprehensive genomic profiling of the autopsy tissue revealed\n                      <jats:italic>BRAF<\/jats:italic>\n                      G466A,\n                      <jats:italic>KRAS<\/jats:italic>\n                      L19F, and\n                      <jats:italic>NF1<\/jats:italic>\n                      Q2324* mutations in addition to\n                      <jats:italic>EGFR<\/jats:italic>\n                      E746_A750del. Anti\u2010cancer treatments with radiation and EGFR\u2010TKIs accompanying these gene alterations might induce the histological transformation and resistance to EGFR\u2010TKIs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      This report adds an insight into the involvement of genetic events in histological transformation in\n                      <jats:italic>EGFR<\/jats:italic>\n                      \u2010mutated lung cancer.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70546","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:40:04Z","timestamp":1776652804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleomorphic Carcinoma With\n                    <scp>\n                      <i>EGFR<\/i>\n                    <\/scp>\n                    and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0380-2713","authenticated-orcid":false,"given":"Yuki","family":"Akazawa","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-1665","authenticated-orcid":false,"given":"Takashi","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Yagami","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Kitasato University School of Medicine  Sagamihara 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