{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:06:08Z","timestamp":1789563968131,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T00:00:00Z","timestamp":1776556800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Surgical resection is the standard treatment for pulmonary metastases from colorectal cancer, but its safety and long\u2010term efficacy in medically inoperable patients remain limited. Percutaneous cryoablation is a minimally invasive alternative to surgical resection and has gained increasing attention in recent years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This retrospective study aimed to evaluate complication rates, local tumor control, and overall survival associated with percutaneous cryoablation for pulmonary metastases from colorectal cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We retrospectively reviewed patients treated with percutaneous cryoablation from 2002\u20132017. Complications were defined as adverse events \u2265\u2009grade 2 per Common Terminology Criteria for Adverse Events version 5.0. In total, 126 metastatic pulmonary tumors in 48 patients were treated across 73 sessions. Complications occurred in 18 sessions (24.7%), including 2 grade \u2265\u20093 events (2.7%). No treatment\u2010related deaths occurred within 30\u2009days. With a median follow\u2010up of 9.7\u2009months (maximum, 155.4\u2009months), local tumor control rates at 1, 3, and 5\u2009years were 74.5%, 58.8%, and 56.4%, respectively. Median overall survival was 3.8\u2009years, with 1\u2010, 3\u2010, 5\u2010, and 10\u2010years rates of 86.8%, 60.4%, 41.9%, and 36.6%, respectively. The relatively short median follow\u2010up should be considered when interpreting these long\u2010term local control estimates. Six patients achieved 10\u2010years survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Percutaneous cryoablation is a safe, minimally invasive option that provides favorable local tumor control and encouraging long\u2010term survival outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70550","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T02:49:59Z","timestamp":1776653399000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Percutaneous Cryoablation Under Local Anesthesia for Pulmonary Metastases From Colorectal Cancer: Long\u2010Term Outcomes From a Single\u2010Institution Retrospective 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