{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:02:19Z","timestamp":1779894139968,"version":"3.53.1"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T00:00:00Z","timestamp":1777334400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100023174","name":"Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi","doi-asserted-by":"publisher","award":["2758\/UN1.DITLIT\/DIT\u2010LIT\/PT\/2020"],"award-info":[{"award-number":["2758\/UN1.DITLIT\/DIT\u2010LIT\/PT\/2020"]}],"id":[{"id":"10.13039\/501100023174","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A number of studies have demonstrated the important role of activation\u2010induced cytidine deaminase (AID) in the pathogenesis of diffuse large B\u2010cell lymphoma (DLBCL). AID has been relatively underexplored as a prognostic factor in DLBCL, and its role remains controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study conducted a comprehensive analysis of the association between AID expression and clinical outcomes in 70 Indonesian patients with DLBCL treated with a standard CHOP \u00b1 rituximab regimen.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Immunostaining results showed that AID was expressed in 35.7% of DLBCL samples. Multivariate analysis indicated that positive AID expression was associated with shorter overall survival (OS) specifically among patients receiving a rituximab\u2010containing regimen, with a hazard ratio of 10.39 (95% CI: 1.93\u201355.96;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The significant prognostic value of AID in the DLBCL subgroup treated with rituximab\u2014but not in the general DLBCL population or in those not receiving rituximab\u2014underscores the potential relevance of AID expression in DLBCL management and treatment decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70557","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T03:16:14Z","timestamp":1777432574000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adverse Prognostic Significance of Activation\u2010Induced Cytidine Deaminase in Diffuse Large B\u2010Cell Lymphoma Patients Treated With R\u2010\n                    <scp>CHOP<\/scp>"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5360-6693","authenticated-orcid":false,"given":"Mardiah Suci","family":"Hardianti","sequence":"first","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-5492","authenticated-orcid":false,"given":"Nungki","family":"Anggorowati","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4186-1769","authenticated-orcid":false,"given":"Syahru Agung","family":"Setiawan","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3110-2718","authenticated-orcid":false,"given":"Miraz Radhea","family":"Bagaskoro","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2045-1795","authenticated-orcid":false,"given":"Johan","family":"Kurnianda","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1365-7699","authenticated-orcid":false,"given":"Kartika Widayati","family":"Taroeno\u2010Hariadi","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-4813","authenticated-orcid":false,"given":"Ibnu","family":"Purwanto","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9236-9435","authenticated-orcid":false,"given":"Susanna Hilda","family":"Hutajulu","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical\u2010Oncology, Department of Internal Medicine Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada\/Dr. Sardjito Hospital  Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18470"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403323"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000139701"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403488"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-02-628164"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-71058-y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2007.35"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/narcan\/zcaa029"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0000000000002653"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02595-w"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-015-2001-7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2017.1410884"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-20-0228"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.31557\/apjcc.2022.7.1.71-78"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.18585\/inabj.v13i1.1421"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1558"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0804295105"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.965312"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.214122"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2021.2021049"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00163"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12753"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1221528"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-24631-5"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13227"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217143"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.02403"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17450"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022009389"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.243626"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70557","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70557","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T14:02:53Z","timestamp":1779890573000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/cnr2.70557"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70557","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,28]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70557"}}