{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:06:06Z","timestamp":1789563966162,"version":"build-2803163510"},"reference-count":82,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Oral squamous cell carcinoma (OSCC) is a common and aggressive cancer sometimes subsequent to oral potentially malignant disorders (OPMDs). Notwithstanding progress in surgical, radiotherapeutic, and chemotherapeutic interventions, survival rates for OSCC continue to be inadequate and are associated with significant functional impairment, underscoring the necessity for preventive and interceptive therapeutic approaches. Chemoprevention has emerged as a viable strategy to inhibit, postpone, or reverse oral carcinogenesis by targeting the molecular and cellular processes implicated in malignant transformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Recent Findings<\/jats:title>\n                    <jats:p>This review synthesizes current evidence on chemopreventive agents investigated in OPMDs and OSCC. Relevant literature was analyzed focusing on natural compounds, synthetic drugs, and targeted biological therapies, as well as emerging delivery approaches.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>Significant emphasis is placed on bioactive phytochemicals such as retinoids, carotenoids (\u03b2\u2010carotene and lycopene), curcumin, resveratrol, black raspberries, and vitamin E, alongside synthetic agents including cyclooxygenase\u20102 inhibitors and epidermal growth factor receptor (EGFR)\u2013targeted therapies. These drugs demonstrate chemopreventive effects via modulating oxidative stress, inflammation, cell cycle regulation, apoptosis, angiogenesis, epithelial\u2013mesenchymal transition, and immune evasion in the tumor microenvironment. Clinical and experimental investigations examined in this review reveal inconsistent, although promising results, including the regression of dysplasia, decreased rates of malignant transformation, and enhanced molecular risk profiles in OPMDs. Nonetheless, obstacles persist about long\u2010term effectiveness, ideal dose, toxicity, and patient adherence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Chemopreventive medicines, especially when utilised in combination and through sophisticated delivery systems, signify a prospective adjunct or alternative approach in the care of OPMDs and OSCC, with the capacity to diminish disease burden and enhance patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70559","type":"journal-article","created":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T03:59:21Z","timestamp":1777089561000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Chemopreventive Agents in the Management of Oral Potentially Malignant Disorders and Oral Cancer: A Narrative Review"],"prefix":"10.1002","volume":"9","author":[{"given":"Lana","family":"Sayal","sequence":"first","affiliation":[{"name":"Faculty of Dentistry, Oral Medicine Department Alwatanyia Private University  Hama Syria"},{"name":"University of Aden  Aden Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"hamadah","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral Medicine Department Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eyad","family":"Chatty","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Pathology Department Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9702-2887","authenticated-orcid":false,"given":"Anas","family":"Abdo","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Endodontic Department  Damascus Syria"},{"name":"International University of Science and Technology  Daraa Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Aghbari","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral Medicine Department University of Aden  Aden Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Munasser","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral and Maxillofacial Surgery Department University of Aden  Aden Yemen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4626-4082","authenticated-orcid":false,"given":"Amirah","family":"Alnour","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry, Oral and Maxillofacial Pathology Department Damascus University  Damascus Syria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,24]]},"reference":[{"key":"e_1_2_17_2_1","first-page":"179","volume-title":"A Review Article","author":"Abbas T. 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