{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:02:31Z","timestamp":1779894151869,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Synchronous cancers, defined as malignancies diagnosed concurrently or within 2\u2009months of each other, are rare, with an incidence of 1%\u20136%. Environmental factors such as tobacco smoking play a significant role in their development. Patients with head and neck squamous cell carcinoma (SCC) are at increased risk of second malignancies, complicating treatment strategies and prognosis. This report presents a rare case of synchronous SCC of the lower lip and papillary thyroid carcinoma (PTC).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 61\u2010year\u2010old male with a history of smoking presented with a 2.5\u2009cm exophytic lesion of the lower lip, diagnosed as keratinizing SCC. A suspicious cervical lymph node was revealed, which intraoperatively demonstrated metastatic PTC. Following partial lip resection and neck dissection, total thyroidectomy was performed, confirming a 1.5\u2009mm PTC focus with micrometastases. The patient underwent adjuvant conventional radiotherapy (RTH) for SCC (66\u2009Gy in 33 fractions) and radioiodine therapy (131\u2010I) for PTC. Post\u2010therapeutic scintigraphy identified suspected micrometastases in the iliac bone, prompting further 131\u2010I treatment. Following completion of therapy, the patient achieved a complete response, with no radiologic or clinical evidence of residual disease from both malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Synchronous SCC of the lip and PTC are exceedingly rare, lacking standardized treatment guidelines. This case highlights the necessity of a multidisciplinary approach, integrating surgery, RTH, and systemic therapy. Careful postoperative histopathological assessment of lymph nodes may reveal unexpected findings that necessitate further diagnostic work\u2010up and a multidisciplinary approach, as this can significantly influence staging, treatment decisions, and patient prognosis, representing an important key learning point.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70564","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:19:38Z","timestamp":1777511978000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Multidisciplinary Approach for a Patient With Synchronous Lip and Thyroid Cancer Involving Radiotherapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9278-3736","authenticated-orcid":false,"given":"Aleksandra","family":"Nasiek","sequence":"first","affiliation":[{"name":"1st Radiation and Clinical Oncology Department Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5185-4004","authenticated-orcid":false,"given":"Pawe\u0142","family":"Polanowski","sequence":"additional","affiliation":[{"name":"1st Radiation and Clinical Oncology Department Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4465-0202","authenticated-orcid":false,"given":"Marek","family":"Hamm","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-1191","authenticated-orcid":false,"given":"Anna","family":"Kozub","sequence":"additional","affiliation":[{"name":"3rd Radiation and Clinical Oncology Department Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8049-0831","authenticated-orcid":false,"given":"Barbara","family":"Lipka","sequence":"additional","affiliation":[{"name":"Department of Periodontal Diseases and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze Medical University of Silesia  Katowice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8086-7346","authenticated-orcid":false,"given":"Agnieszka","family":"Kotecka\u2010Blicharz","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Endocrine Oncology Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0554-6171","authenticated-orcid":false,"given":"Krzysztof","family":"Sk\u0142adowski","sequence":"additional","affiliation":[{"name":"1st Radiation and Clinical Oncology Department Maria Sklodowska\u2010Curie National Research Institute of Oncology  Gliwice Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12081940"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.27988"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2020.104717"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz400"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen\u20102017\u2010000172"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/tjps.TJPS_28_18"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196605000-00002"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4317\/medoral.19595"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2006.03.054"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300891621996805"},{"key":"e_1_2_10_13_1","volume-title":"NCCN Clinical Practice Guidelines in Oncology: Thyroid Carcinoma. 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