{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T15:02:02Z","timestamp":1779894122975,"version":"3.53.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Choriocarcinoma is a highly aggressive malignant tumor composed primarily of cytotrophoblast and syncytiotrophoblast cells without villi and is characterized by beta\u2010human chorionic (beta\u2010hCG) gonadotropin production. Although most cases are of gestational origin, rare non\u2010gestational choriocarcinomas may arise from pluripotent germ cells in extragenital locations, independently of pregnancy. Primary pulmonary choriocarcinoma is extremely rare, and kidney metastasis has only exceptionally been reported in the literature.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We present the case of a 43\u2010year\u2010old patient with this unusual presentation. The diagnostic process began with a suspected implantation of unknown location and culminated in the final histopathological diagnosis based on lobectomy and nephrectomy specimens, including molecular genetic identification of the pulmonary tumor. Following thoracic and renal surgery, the patient received adjuvant chemotherapy and immunotherapy with anti\u2010PD\u20101 monoclonal antibodies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case highlighted the diagnostic challenges posed by primary pulmonary choriocarcinoma with renal metastasis, an exceptionally rare clinical entity. Ongoing follow\u2010up includes regular imaging studies and beta\u2010hCG monitoring.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70578","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T13:12:21Z","timestamp":1778850741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Primary Pulmonary Choriocarcinoma Metastasizing to the Kidney: Diagnostic and Therapeutic Complexities"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8220-3511","authenticated-orcid":false,"given":"Zor\u00e1n","family":"Belics","sequence":"first","affiliation":[{"name":"Sz\u00e9chenyi Istv\u00e1n University  Gy\u0151r Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9117-5048","authenticated-orcid":false,"given":"Ant\u00f3nia","family":"F\u00fcrich","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1207-2258","authenticated-orcid":false,"given":"Levente","family":"Bogy\u00f3","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Oncology Institute  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-4409-9217","authenticated-orcid":false,"given":"Hanna","family":"Tihanyi","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery National Oncology Institute  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0392-8025","authenticated-orcid":false,"given":"M\u00e1ria","family":"Madar\u00e1sz","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-4107-9784","authenticated-orcid":false,"given":"Dorottya","family":"R\u00f3zsa","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8272-2627","authenticated-orcid":false,"given":"Gizella","family":"Moln\u00e1r","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7667-3837","authenticated-orcid":false,"given":"Bal\u00e1zs","family":"G\u00e9recz","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1267-7364","authenticated-orcid":false,"given":"Petronella","family":"Hupuczi","sequence":"additional","affiliation":[{"name":"Maternity Private Department of Obstetrics and Gynecology  Budapest Hungary"},{"name":"Semmelweis University  Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc\u20102023\u2010004906"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-2627"},{"key":"e_1_2_10_4_1","first-page":"1905","article-title":"Primary Choriocarcinoma of the Lung","volume":"24","author":"Umemori Y.","year":"2004","journal-title":"Anticancer Research"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000336784"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/raon\u20102016\u20100038"},{"key":"e_1_2_10_7_1","first-page":"2352","article-title":"Primary Choriocarcinoma of the Lung: A Case Report and Literature Review","volume":"13","author":"Wu P. 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