{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:53Z","timestamp":1786390853481,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T00:00:00Z","timestamp":1780012800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n The recent fifth edition of World Health Organization and International Consensus Classification in 2022 recognized\n TP53<\/jats:italic>\n \u2010mutated myelodysplastic neoplasms (MDS) as a distinct entity requiring multi\u2010hit classification. Literatures indicate that\n TP53<\/jats:italic>\n variant alle frequency (VAF) correlates with clinical outcomes. However, comprehensive studies that characterize the full mutation landscape and clinical correlations in Asian populations are still limited.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n This research aims to elucidate the mutation spectrum and baseline characteristics of\n TP53<\/jats:italic>\n \u2010mutated MDS in a Chinese cohort, thereby enhancing clinical understanding and treatment approaches.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n A total of 161\n TP53<\/jats:italic>\n \u2010mutated patients from 1589 newly diagnosed MDS with next\u2010generation sequencing (NGS) data via a targeted 96\u2010gene sequencing panel were analyzed to assess genomic alterations. Among 161\n TP53<\/jats:italic>\n \u2010mutated patients (10.1% of 1589 MDS cases), we identified a predominance of missense mutations (76.9%) and frequent co\u2010occurrence with epigenetic modifiers, notably\n DNMT3A<\/jats:italic>\n (11.8%),\n TET2<\/jats:italic>\n (10.6%), and\n ASXL1<\/jats:italic>\n (9.3%). Critically,\n TP53<\/jats:italic>\n VAF correlated strongly with disease severity parameters, including hemoglobin levels, blast percentage, karyotype, and International Prognostic Scoring System (IPSS), revised IPSS (IPSS\u2010R) risk and IPSS\u2010Molecular (IPSS\u2010M) classifications (all\n p<\/jats:italic>\n \u2009<\u20090.05), suggesting that\n TP53<\/jats:italic>\n VAF serves as an important biomarker for risk stratification. In addition, patients with multiple\n TP53<\/jats:italic>\n mutations harbored significantly worse IPSS, IPSS\u2010R, and IPSS\u2010M risk classifications compared to those with a single\n TP53<\/jats:italic>\n mutation.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n This study underscores the importance of\n TP53<\/jats:italic>\n mutations in Asian MDS patients, contributing to genetic profiling in risk stratification and therapeutic decision\u2010making.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70584","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T15:54:35Z","timestamp":1780070075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic and Clinical Features in\n TP53<\/i>\n \u2010Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next\u2010Generation Sequencing Data"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2510-6983","authenticated-orcid":false,"given":"Yanming","family":"Cheng","sequence":"first","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7529-5215","authenticated-orcid":false,"given":"Lixia","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Acornmed Biotechnology Co. Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1246-7671","authenticated-orcid":false,"given":"Yu","family":"Gao","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0340-7401","authenticated-orcid":false,"given":"Yifei","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7045-3816","authenticated-orcid":false,"given":"Wei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8844-1123","authenticated-orcid":false,"given":"Hong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Acornmed Biotechnology Co. Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4721-0016","authenticated-orcid":false,"given":"Jiayue","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Medical Affairs Acornmed Biotechnology Co. Ltd. Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2364-5719","authenticated-orcid":false,"given":"Yudi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"},{"name":"Myelodysplastic Syndromes Diagnosis and Therapy Center The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China"},{"name":"Cancer Center, Zhejiang University Hangzhou China"},{"name":"Zhejiang Provincial Key Lab of Hematopoietic Malignancy, Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020078"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023020079"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.216767"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.20106"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.07.001"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024534"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013343"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01613-1"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-023-01480-y"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010312"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-023-00821-x"},{"issue":"6","key":"e_1_2_13_14_1","first-page":"1304","article-title":"Clinical Interrogation of TP53 Aberrations and Its Impact on Survival in Patients With Myeloid Neoplasms","volume":"110","author":"Senapati J.","year":"2025","journal-title":"Haematologica"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024023840"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2023023727"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2025029727"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1008-z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014472"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2019001101"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19247"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011304"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24252"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19895"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200008"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-024-01077-9"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-018-0351-2"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006239"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018236"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-08-518886"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26845"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-021-01162-8"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-22-0332"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70584","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70584","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70584","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:13:45Z","timestamp":1786389225000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,29]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cnr2.70584"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70584","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,29]]},"assertion":[{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70584"}}