{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:47Z","timestamp":1786390847483,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer is the most common non\u2010cutaneous malignancy in men and remains a leading cause of cancer\u2010related mortality, particularly in aggressive variants. These tumors are usually associated with alterations in TP53, RB1, and PTEN. The microphthalmia\u2010associated transcription factor (MITF) has been implicated in several malignancies, but its role in prostate cancer is less defined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We report the first case of metastatic prostate adenocarcinoma harboring a gain\u2010of\u2010function MITF E318K mutation. The patient presented with high tumor burden, rapid progression, and evidence of tumor heterogeneity. The E318K mutation, previously linked to melanoma and renal cell carcinoma, enhances MITF transcriptional activity and may contribute to aggressive disease behavior.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case expands current understanding of MITF in prostate cancer and raises important questions regarding its prognostic and therapeutic significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70588","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:41:43Z","timestamp":1780299703000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>MITF<\/scp>\n                    Gain\u2010of\u2010Function Mutation in Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3878-6240","authenticated-orcid":false,"given":"Paul J.","family":"Pecorin","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3428-2530","authenticated-orcid":false,"given":"Nyembezi","family":"Dhliwayo","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical Oncology and Cell Therapy, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7560-9598","authenticated-orcid":false,"given":"Matthew","family":"Demetrious","sequence":"additional","affiliation":[{"name":"Department of Pathology Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9676-0789","authenticated-orcid":false,"given":"Ludimila","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Division of Hematology &amp; Oncology, Department of Medicine University of Virginia  Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Rodriguez\u2010Bravo","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Comprehensive Cancer Center  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7870-7511","authenticated-orcid":false,"given":"Josep","family":"Domingo\u2010Domenech","sequence":"additional","affiliation":[{"name":"Department of Urology Mayo Comprehensive Cancer Center  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8107-4055","authenticated-orcid":false,"given":"Thomas","family":"Westbrook","sequence":"additional","affiliation":[{"name":"Division of Hematology, Medical Oncology and Cell Therapy, Department of Medicine Rush University Medical Center  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21763"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41585\u2010020\u20100298\u20108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15245843"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2012.12.006"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2017.99"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03664"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201007\u20102491"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201013\u20100424"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6712"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010018\u20101096\u20106"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159\u20108290.CD\u201023\u20100306"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10539"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10630"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698\u2010024\u201000667\u2010x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4307"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aah4199"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5137"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422\u2010022\u201000744\u20105"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118367"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010025\u201067297\u20100"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70588","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70588","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70588","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:13:35Z","timestamp":1786389215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cnr2.70588"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70588","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70588"}}