{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:00:11Z","timestamp":1785304811221,"version":"3.55.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200233"],"award-info":[{"award-number":["82200233"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400253"],"award-info":[{"award-number":["82400253"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although inotuzumab ozogamicin (InO) has been approved as an effective agent for patients with refractory\/relapsed (r\/r) B\u2010cell acute lymphoblastic leukemia (B\u2010ALL), data in the context of post chimeric antigen receptor (CAR)\u2010T cell therapy and allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT) relapse are lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We report on a series of three heavily pretreated r\/r B\u2010ALL patients who relapsed after CAR\u2010T therapy and allo\u2010HSCT and were salvage treated with InO. All achieved bone marrow (BM) remission with negative minimal residual disease (MRD) after the first InO cycle; of note, one patient with extensive extramedullary involvement before InO treatment experienced a remarkable tumor regression on PET\/CT imaging. They all completed 2\u2009cycles of InO. Two patients experienced relapse 8 and 9.5\u2009months after InO initiation (one central nervous system relapse, the other breast relapse). Treatment\u2010related adverse events (AEs) were primarily hematologic and manageable. Crucially, no sinusoidal obstruction syndrome (SOS) developed in any of the patients during the whole course of InO therapy and beyond.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>InO appears to be a promising and well\u2010tolerated salvage regimen for inducing remission in heavily pretreated B\u2010ALL patients who have relapsed after both CAR\u2010T therapy and allo\u2010HSCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70601","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:39:11Z","timestamp":1782967151000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Salvage Therapy With Inotuzumab Ozogamicin in Relapsed\/Refractory B\u2010\n                    <scp>ALL<\/scp>\n                    After\n                    <scp>CAR<\/scp>\n                    \u2010T Therapy and\n                    <scp>HSCT<\/scp>\n                    : A Case Series"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3812-7421","authenticated-orcid":false,"given":"Honghu","family":"Li","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University  Hangzhou China"},{"name":"Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luxin","family":"Yang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Lai","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8762-278X","authenticated-orcid":false,"given":"Lixia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Center, the First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2353-1896","authenticated-orcid":false,"given":"Kui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, the First Affiliated Hospital, College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Ultrasound in Medicine The Second Affiliated Hospital of Zhejiang University School of Medicine, Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-1621","authenticated-orcid":false,"given":"He","family":"Huang","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation 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