{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:51Z","timestamp":1786390851601,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Combination immunotherapy is widely used as first\u2010line treatment for metastatic renal cell carcinoma (mRCC), but pretreatment prognostic stratification remains insufficiently established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the performance of various prognostic scores in the first\u2010line treatment of metastatic renal cell carcinoma (mRCC) with combination immunotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>We retrospectively analyzed 145 patients who started first\u2010line combination immunotherapy at six institutions from December 2015 to February 2025. We calculated IMDC, LIPI, RMH, PMHI, GRIm, C\u2010PLAN, mGPS, and Meet\u2010URO scores and performed survival (PFS, OS) and ROC analyses (PD, ORR). Survival analyses also evaluated the prognostic ability of each score by concordance index. At a median follow\u2010up period of 28.8 months, the median progression\u2010free survival (PFS) was 35.1 months and the median overall survival (OS) was not reached. Kaplan\u2010Meier analysis showed significant differences for all scores except between IMDC and C\u2010PLAN (PFS) and IMDC and mGPS (OS). Among these, PMHI and RMH demonstrated superior results in the C\u2010index. ROC analysis showed no score had prognostic value for PD or ORR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PMHI and RMH may be useful prognostic scores for survival outcomes in mRCC patients treated with immunotherapy. However, their ability to predict treatment efficacy (ORR and PD) is limited and further research is needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70604","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T04:39:38Z","timestamp":1781671178000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of Multiple Prognostic Scores in Patients With Metastatic Renal Cell Carcinoma Receiving First\u2010Line, Immune\u2010Based Combinations"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1254-0001","authenticated-orcid":false,"given":"Hiromichi","family":"Sakurai","sequence":"first","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8610-0149","authenticated-orcid":false,"given":"Masanobu","family":"Shiga","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4621-8470","authenticated-orcid":false,"given":"Shuya","family":"Kandori","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akifumi","family":"Omiya","sequence":"additional","affiliation":[{"name":"Department of Urology Ibaraki Prefectural Central Hospital  Mito Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1261-0766","authenticated-orcid":false,"given":"Tomoki","family":"Ishida","sequence":"additional","affiliation":[{"name":"Department of Urology Ibaraki Prefectural Central Hospital  Mito Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6941-0750","authenticated-orcid":false,"given":"Kotoe","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Urology Hitachi General Hospital  Hitachi Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bunpei","family":"Isoda","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan J.","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Komine","sequence":"additional","affiliation":[{"name":"Department of Urology Tsukuba Medical Center Hospital  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iinuma","sequence":"additional","affiliation":[{"name":"Department of Urology National Hospital Organization Mito Medical Center  Mito Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Joraku","sequence":"additional","affiliation":[{"name":"Department of Urology Ibaraki Prefectural Central Hospital  Mito Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1144-2755","authenticated-orcid":false,"given":"Hiromitsu","family":"Negoro","sequence":"additional","affiliation":[{"name":"Department of Urology Hitachi General Hospital  Hitachi Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Tsutsumi","sequence":"additional","affiliation":[{"name":"Department of Urology Hitachi General Hospital  Hitachi Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamitsu","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Urology International University of Health and Welfare Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Urology International University of Health and Welfare Narita Hospital  Narita Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Nishiyama","sequence":"additional","affiliation":[{"name":"Department of Urology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,16]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Network NCC \u201cNCCN Clinical Practice Guidelines in Oncology: Kidney Cancer. Version 3.2025 \u201d2025 https:\/\/www.nccn.org\/professionals\/physician_gls\/PDF\/kidney.pdf."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cti2.1471"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-023-03317-z"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-024-03933-w"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1368749"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.21.4809"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2023.1822"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2022.100634"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092662"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2023.05.021"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.4771"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6604218"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-11-426"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.07.027"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.14798"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6606087"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/17588359211019642"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.15586\/jkcvhl.v12i4.403"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14186385"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.23736\/S1824-4785.20.03250-1"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12271-0"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041066"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2024.114048"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1173025"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.06.003"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2025.07.018"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clgc.2023.10.001"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgo.2025.102336"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13934-2"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16101835"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1193"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.14740\/wjon1275"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14072217"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-020-02637-1"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0315-0"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70604","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:13:40Z","timestamp":1786389220000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/cnr2.70604"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70604","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70604"}}