{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:47Z","timestamp":1786390847916,"version":"build-2736575974"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770217"],"award-info":[{"award-number":["81770217"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872322"],"award-info":[{"award-number":["81872322"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017531","name":"Medical and Health Research Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2025KY1265"],"award-info":[{"award-number":["2025KY1265"]}],"id":[{"id":"10.13039\/501100017531","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The 5th edition of the World Health Organization (WHO) classification updated the term for acute myeloid leukemia with myelodysplasia\u2010related changes (AML\u2010MRC) to acute myeloid leukemia, myelodysplasia\u2010related (AML\u2010MR), along with new diagnostic criteria. However, the clinical prognostic outcomes of patients diagnosed with AML\u2010MR based on the new WHO definition remain poorly defined, and the optimal frontline treatment strategy for this patient population has not been fully clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to compare the clinical efficacy and survival outcomes of three mainstream frontline treatment regimens for newly diagnosed AML\u2010MR patients and identify independent prognostic factors affecting patient survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We collected data from 142 patients with newly diagnosed AML\u2010MR and divided them into three cohorts depending on different frontline therapies: low\u2010intensity chemotherapy (LIC), intensive chemotherapy (IC), and venetoclax plus hypomethylating agent (VEN\/HMA). The overall response rate in the VEN\/HMA cohort was higher than in the LIC or IC cohort (VEN\/HMA vs. LIC, 72.7% vs. 42.1%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010; VEN\/HMA vs. IC, 72.7% vs. 54.3%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.049). Event\u2010free survival (EFS) in the LIC cohort was inferior to that in the IC cohort (median 2.5 vs. 4.8\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.037) or VEN\/HMA cohort (median 2.5 vs. 6.4\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006). The overall survival (OS) in the LIC cohort was inferior to that in the IC cohort (median 11.9 vs. 19.4\u2009months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009). No statistically significant differences in EFS or OS were observed between the IC and VEN\/HMA cohorts. Multivariate analyses showed that prior HMA exposure and frontline LIC therapy were associated with inferior EFS, and allogeneic hematopoietic stem cell transplantation was associated with better EFS and OS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study suggests that in patients with AML\u2010MR, frontline therapy with VEN\/HMA or IC improves outcomes compared with LIC. Allogeneic hematopoietic stem cell transplantation is encouraged for all eligible patients with AML\u2010MR.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70607","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T04:32:00Z","timestamp":1782102720000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Frontline Treatment Strategies on Outcomes in Patients With Acute Myeloid Leukemia, Myelodysplasia\u2010Related"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1604-5337","authenticated-orcid":false,"given":"Yi","family":"Li","sequence":"first","affiliation":[{"name":"Bone Marrow Transplantation Center The First Affiliated Hospital, Zhejiang University School of Medicine  Hangzhou China"},{"name":"Liangzhu Laboratory, Zhejiang University Medical Center  Hangzhou China"},{"name":"Institute of Hematology, Zhejiang University 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