{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:33Z","timestamp":1786390833479,"version":"build-2736575974"},"reference-count":75,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T00:00:00Z","timestamp":1782000000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This systematic review and meta\u2010analysis aimed to clarify the prognostic impact of human epidermal growth factor receptor 2 (HER2) overexpression on overall survival (OS) and progression\u2010free survival (PFS) in advanced and resectable gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched electronic databases for studies reporting survival outcomes associated with HER2 overexpression in gastric cancer patients. Hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were pooled using random\u2010effects models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 39 studies with 19\u2009903 gastric cancer patients were included. The pooled rate of HER2 overexpression was estimated at 16% (95% CI, 14% to 18%). Our analysis revealed that HER2 overexpression was significantly associated with worse OS (HR\u2009=\u20091.30, 95% CI 1.12 to 1.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and PFS (HR\u2009=\u20091.57, 95% CI: 1.09 to 2.26;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01). The association with worse OS was significant across the studies with resectable (HR\u2009=\u20091.31, 95% CI: 1.08 to 1.60;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and advanced (HR\u2009=\u20091.25, 95% CI: 1.00 to 1.58;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.04) gastric cancer patients. However, the association between HER2 and PFS was only significant in the resectable subgroups (HR\u2009=\u20092.28, 95% CI: 1.09 to 4.74;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01), not in the advanced subgroup (HR\u2009=\u20091.18, 95% CI: 0.93 to 1.51;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.16).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HER2 overexpression appears to be associated with poorer outcomes in advanced and resectable gastric cancer. Standardizing diagnostic criteria and integrating HER2 assessment into multimarker panels could enhance prognostic accuracy and guide personalized therapeutic decisions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70612","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T03:51:42Z","timestamp":1782100302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Utility of\n                    <scp>HER2<\/scp>\n                    Overexpression in Prognosis of Gastric Cancer: A Systematic Review and Meta\u2010Analysis Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7712-9427","authenticated-orcid":false,"given":"Seyed Morteza","family":"Pourfaraji","sequence":"first","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-967X","authenticated-orcid":false,"given":"Alireza","family":"Abdollahi","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, IKHC Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6675-6998","authenticated-orcid":false,"given":"Fatemeh Ojaghi","family":"Shirmard","sequence":"additional","affiliation":[{"name":"School of Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1162-2019","authenticated-orcid":false,"given":"Reza","family":"Ghalehtaki","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center, Cancer Research Institute, IKHC Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Radiation Oncology, Cancer Institute, IKHC Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1507-4494","authenticated-orcid":false,"given":"Samaneh","family":"Salarvand","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, IKHC Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2022.102418"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2023.104216"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes15070903"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.21037\/jgo-23-464"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2024.25.9.2979"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16030618"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2024.5624"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-06024-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-023-00998-y"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-025-13749-1"},{"key":"e_1_2_11_12_1","unstructured":"G. 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