{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:40:36Z","timestamp":1786390836486,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,6]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Cancer\u2010related fatigue (CrF), a prevalent and debilitating symptom among cancer patients, remains underrecognized and unstandardized in routine oncology care. To address this, we introduced a new digital tool for daily CrF measurement and integration in routine cancer treatment.<\/jats:p>\n <\/jats:sec>\n \n Case<\/jats:title>\n This case series investigates the use of the ePROtect app for daily CrF assessment in two pediatric acute lymphoblastic leukemia (ALL) patients. Data were collected up to 2\u2009weeks after the end of intensive therapy (before the start of maintenance) and analyzed using two questions informed by the National Comprehensive Cancer Network (NCCN), each offering five possible responses and categorizing fatigue into different subclasses. This analysis compares two 3\u2010year\u2010old girls with pre\u2010B ALL, one with standard risk (SR) and favorable genetics, the other one with poor therapy response and stratified to high risk (HR) treatment. The SR patient responded well to treatment, experiencing severe CrF on only 6% of the treatment days. In contrast, the HR patient required intensified treatment with multiple re\u2010induction phases, resulting in more frequent hospitalizations and severe CrF on 19.4% of the treatment days. CrF assessments were conducted daily for both patients, achieving 98.6% and 69.5% completion rates throughout intensive therapy, for the SR and HR patient, respectively.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n This case series illustrates the feasibility and potential suitability of our tool using PROMs for CrF assessment. Furthermore, it highlights the correlation between treatment intensity, complications, and CrF levels, underlying the importance of systematically measuring fatigue in cancer patients. Such measurement may inform future efforts to develop and refine individualized supportive care strategies.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70616","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T04:19:23Z","timestamp":1782274763000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Case Series: Can Daily Patient\u2010Reported Outcome Measures Be Implemented for Cancer\u2010Related Fatigue?"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0180-4848","authenticated-orcid":false,"given":"Alexander","family":"Tilg","sequence":"first","affiliation":[{"name":"Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7749-5334","authenticated-orcid":false,"given":"Andreas","family":"Meryk","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes G.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-6275","authenticated-orcid":false,"given":"Roman","family":"Crazzolara","sequence":"additional","affiliation":[{"name":"Medical University of Innsbruck Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-018-4555-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2014.127"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864-020-0707-5"},{"key":"e_1_2_9_5_1","volume-title":"Cancer\u2010Related Fatigue NCCN Clinical Practice Guidelines 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