{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:00:10Z","timestamp":1785304810749,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lung cancer remains a leading cause of cancer\u2010related mortality worldwide, with few effective treatment options available for advanced stages. Canakinumab, an IL\u20101\u03b2 inhibitor, has been investigated as a potential therapeutic agent due to its role in modulating tumor\u2010promoting inflammation. However, its clinical efficacy and safety in NSCLC (non\u2010small cell lung cancer) continue to be uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We aimed to evaluate the efficacy and safety of canakinumab compared with other standard therapies in NSCLC treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>A systematic review was conducted in accordance with PRISMA guidelines. Four electronic databases (PubMed, Scopus, Web of Science, and Embase) were searched for clinical trials assessing canakinumab for NSCLC. Eligible studies included phase I\u2013III clinical trials. The Synthesis Without Meta\u2010analysis (SWiM) guidelines were followed due to substantial heterogeneity in studies. Outcomes evaluated included objective response rate (ORR), progression\u2010free survival (PFS), overall survival (OS), major pathologic response (MPR), and treatment\u2010related adverse events.<\/jats:p>\n                    <jats:p>\n                      Five clinical trials (three phase\n                      <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>\n                      , one phase\n                      <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>\n                      , and one phase\n                      <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content>\n                      ) met the inclusion criteria, with sample sizes ranging from 88 to 1382 patients. The included studies evaluated canakinumab in four distinct clinical settings: adjuvant therapy after complete resection (\n                      <jats:styled-content style=\"fixed-case\">CANOPY<\/jats:styled-content>\n                      \u2010A), first\u2010line treatment in combination with pembrolizumab plus chemotherapy (\n                      <jats:styled-content style=\"fixed-case\">CANOPY<\/jats:styled-content>\n                      \u20101) or spartalizumab plus chemotherapy, second\u2010line treatment in combination with docetaxel (\n                      <jats:styled-content style=\"fixed-case\">CANOPY<\/jats:styled-content>\n                      \u20102), and neoadjuvant therapy with or without pembrolizumab (\n                      <jats:styled-content style=\"fixed-case\">CANOPY<\/jats:styled-content>\n                      \u2010N). Compared to standard therapies, canakinumab did not significantly improve\n                      <jats:styled-content style=\"fixed-case\">ORR<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\n                      ,\n                      <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>\n                      , or\n                      <jats:styled-content style=\"fixed-case\">MPR<\/jats:styled-content>\n                      across any clinical setting. Safety analysis showed comparable adverse event rates between intervention and control groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Despite its promising mechanistic rationale, Canakinumab did not show significant clinical benefits in NSCLC. Although it is generally well tolerated, its role in NSCLC treatment remains uncertain. Future research should concentrate on identifying predictive biomarkers and optimizing combination strategies to enhance its therapeutic potential.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70627","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T22:21:09Z","timestamp":1784758869000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Canakinumab Compared With Standard Therapy for the Treatment of Non\u2010Small Cell Lung Cancer (\n                    <scp>NSCLC<\/scp>\n                    ): A Systematic Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5273-2200","authenticated-orcid":false,"given":"Kamiar","family":"Izadpanah","sequence":"first","affiliation":[{"name":"HIV\/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in 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