{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:50:25Z","timestamp":1791888625849,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Triple\u2010negative breast cancer (TNBC) is a subtype of breast cancer with the poorest prognosis and aggressive biological behavior. In Indonesia, approximately 15%\u201325% of breast cancer cases fall into the TNBC category. One of the biological markers involved in the epithelial\u2013mesenchymal transition (EMT) process and tumor progression of TNBC is vimentin. Positive vimentin expression has been reported to correlate with reduced survival; however, data in the Indonesian population remain limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 29 TNBC patients who received treatment at Dr. Cipto Mangunkusumo National General Hospital between 2017 and 2022, with a 3\u2010year follow\u2010up period. Clinicopathological data and vimentin expression were analyzed using bivariate analysis and Kaplan\u2013Meier survival analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Most patients were aged \u2265\u200940\u2009years (82.8%), had a normal body mass index (82.8%), presented with locally advanced disease (72.4%), high histopathological grade (62.1%), and high Ki\u201067 expression (72.4%). A significant association was observed between vimentin expression and overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.019), where increased vimentin expression was associated with reduced survival (mean survival 30.42\u2009months in the negative group vs. 20.86\u2009months in the positive group). Vimentin expression was also significantly associated with Ki\u201067 expression (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.045), indicating a link between cellular proliferation and activation of EMT. Further analysis in patients with TNBC demonstrated that positive vimentin expression significantly increased the risk of mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.015; HR 5.64; 95% CI 1.39\u201322.7), while inadequate treatment was also associated with poorer overall survival (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011; HR 4.05; 95% CI 1.37\u201311.9).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Vimentin expression is significantly associated with reduced overall survival in patients with TNBC and correlates with high Ki\u201067 expression, reflecting tumor aggressiveness and activation of EMT. Inadequate treatment also contributes to poorer survival outcomes. These findings highlight the potential role of vimentin as a prognostic molecular marker in TNBC within the Indonesian population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70632","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T10:26:17Z","timestamp":1791887177000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prognostic Role of Vimentin Expression in Triple\u2010Negative Breast Cancer: A Retrospective Cohort Study"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4149-4281","authenticated-orcid":false,"given":"Erwin","family":"Danil Yulian","sequence":"first","affiliation":[{"name":"Division of Surgical Oncology, Department of Surgery, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9277-5628","authenticated-orcid":false,"given":"Tantri","family":"Hellyanti","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0526-9406","authenticated-orcid":false,"given":"Karl Heinz Leonhardt","family":"Rowika","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Medicine Universitas Indonesia  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"issue":"3","key":"e_1_2_13_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_13_3_1","doi-asserted-by":"crossref","first-page":"575317","DOI":"10.3389\/fonc.2020.575317","article-title":"Analysis of CK5\/6 and EGFR and Its Effect on Prognosis of Triple Negative Breast Cancer","volume":"10","author":"Wang Z.","year":"2021","journal-title":"Frontiers in Oncology"},{"issue":"31","key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"3997","DOI":"10.1200\/JCO.2013.50.9984","article-title":"Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast","volume":"31","author":"Wolff A. 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