{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:04:53Z","timestamp":1789563893949,"version":"build-2803163510"},"reference-count":39,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T00:00:00Z","timestamp":1785369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the proportion of expressed programmed cell death ligands\u20101 (PD\u2010L1) in epithelial ovarian carcinoma patients, and the association with the clinicopathological, surgical outcomes, and oncologic outcomes. To compare PD\u2010L1 protein expression with messenger ribonucleic acid (mRNA) expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The patients who had pathology of epithelial ovarian\/tubal\/peritoneal carcinoma were enrolled. The demographic data, tumor characteristics, surgical outcomes, treatment details, and treatment response were analyzed by descriptive statistics. Spearman's rank correlation coefficient test was used to determine the correlation between protein expression and mRNA expression. The survival curve was developed utilizing the Kaplan\u2010Meier method, the log\u2010rank test was used to compare survival distributions of patients according to the PD\u2010L1 protein expression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 100 patients, with high\u2010grade serous carcinoma being the most common subtype (42%). Advanced\u2010stage disease was present in 49% of patients, and 65% achieved optimal cytoreduction. PD\u2010L1 protein expression was detected in 23% of tumors, while the median normalized mRNA expression was 0.015 (IQR 0.004\u20130.037). A moderate positive correlation was observed between PD\u2010L1 protein and mRNA expression (Spearman's rho\u2009=\u20090.407,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). The mean progression\u2010free survival (PFS) and overall survival (OS) were 44.32\u2009\u00b1\u20094.04\u2009months and 74.19\u2009\u00b1\u20093.33\u2009months, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>PD\u2010L1 protein expression was observed in a minority of patients and was not significantly associated with survival outcomes. There was a moderate correlation between PD\u2010L1 protein and mRNA expressions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70636","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:15:07Z","timestamp":1785420907000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival Impact of Programmed Cell Death Ligand\u20101 Expression in Patients With Epithelial Ovarian Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5785-3598","authenticated-orcid":false,"given":"Achjima","family":"Tankul","sequence":"first","affiliation":[{"name":"Gynecologic Oncology Division, Department of Obstetrics &amp; Gynecology, Faculty of Medicine Siriraj Hospital Mahidol University  Bangkok Thailand"},{"name":"Charoenkrung Pracharak Hospital  Bangkok 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