{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:04:53Z","timestamp":1789563893753,"version":"build-2803163510"},"reference-count":40,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T00:00:00Z","timestamp":1787184000000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian cancer has the highest mortality among gynecologic malignancies, and acquired resistance to paclitaxel severely limits its clinical efficacy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This study aimed to investigate whether the ANXA1\/FPR axis contributes to paclitaxel resistance in ovarian cancer and to elucidate the underlying molecular mechanisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Using the ANXA1 mimetic peptide Ac2\u201026 and the FPR antagonist Boc2, we provided pharmacological evidence that activation of the ANXA1\/FPR axis promotes paclitaxel resistance in ovarian cancer cells. Mechanistically, ANXA1\/FPR signaling activated the PI3K\/AKT pathway and upregulated PGC1\u03b1, leading to enhanced mitochondrial biogenesis and adaptive energy metabolism remodeling, which in turn prevented paclitaxel\u2010induced cell death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that the ANXA1\/FPR\/PI3K\/AKT\/PGC1\u03b1 axis may represent a potential therapeutic target for overcoming paclitaxel resistance in ovarian cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70637","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T08:15:15Z","timestamp":1787213715000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ANXA1<\/scp>\n                    \/\n                    <scp>FPR<\/scp>\n                    Signaling Contribute to Paclitaxel Resistance in Ovarian Cancer Through\n                    <scp>PI3K<\/scp>\n                    \/\n                    <scp>AKT<\/scp>\n                    \u2010Associated\n                    <scp>PGC1\u03b1<\/scp>\n                    Regulation"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1043-7698","authenticated-orcid":false,"given":"Zhou","family":"Li","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Hospital of Jilin University  Changchun Jilin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-3124-5128","authenticated-orcid":false,"given":"Jiang","family":"Mingrui","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The First Hospital of Jilin University  Changchun Jilin 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