{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:07Z","timestamp":1790618227762,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Breast cancer remains a topic of interest due to its high mortality rate among Cameroonian women. The barks of\n Erythrina excelsa<\/jats:italic>\n are traditionally used for medicinal purposes in the management of various conditions including cancer.\n <\/jats:p>\n <\/jats:sec>\n \n Aims<\/jats:title>\n \n This study evaluated the phytochemical composition, antioxidant properties, and anticancer effects of\n Erythrina excelsa<\/jats:italic>\n bark extract in\u00a0vitro and in\u00a0vivo.\n <\/jats:p>\n <\/jats:sec>\n \n Methods and Results<\/jats:title>\n \n Phytochemical profiling and antioxidant assays (DPPH, FRAP) were conducted to determine secondary metabolite content and free radical scavenging capacity. Cytotoxicity, apoptosis, and cell cycle arrest were assessed in MCF\u20107 and MDA\u2010MB\u2010231 breast cancer cell lines. In\u00a0vivo chemopreventive efficacy was evaluated using a DMBA\u2010induced mammary carcinogenesis in 42 female rats aged 55 to 65\u2009days (~100\u2009g), except the normal group (\n n<\/jats:italic>\n \u2009=\u20097). The normal (NOR) and negative (DMBA) groups were treated daily with the vehicle (2% ethanol in distilled water) while the positive (Tamox) and test groups received tamoxifen (3.3\u2009mg\/kg) and\n Erythrina excelsa<\/jats:italic>\n extract (75, 150, 300\u2009mg\/kg BW), respectively for 20\u2009weeks. Tumor parameters, serum biomarkers (CA 15\u20133, cytokines), oxidative stress markers, hematological and biochemical indices, and organ toxicity were assessed. As results, both aqueous (AE) and ethanolic (EE) extracts of\n \n E. excelsa<\/jats:italic>\n <\/jats:styled-content>\n inhibited the growth of MCF\u20107 and MDA\u2010MB\u2010231 breast cancer cells in a dose\u2010dependent manner after 24\u2009h, induced apoptosis, and promoted G2\/M cell cycle arrest. In\u00a0vivo,\n \n E. excelsa<\/jats:italic>\n <\/jats:styled-content>\n aqueous extract (AE) significantly reduced tumor incidence, volume, and weight in a DMBA\u2010induced mammary carcinogenesis rat model, while lowering serum CA15\u20103 and pro\u2010inflammatory cytokines (IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20106, IL\u201012). Treatment also enhanced antioxidant defenses (SOD, catalase, GSH), reduced lipid peroxidation (MDA), improved hematological and biochemical parameters, and mitigated DMBA\u2010induced hepatic and renal toxicity, without evidence of systemic side effects.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Erythrina excelsa<\/jats:italic>\n barks exhibited an anticancer potential mediated by its antioxidant, anti\u2010inflammatory, pro\u2010apoptotic, and cell cycle\u2013modulating effects, and support its further investigation as a promising natural source for cancer therapy.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/cnr2.70642","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T07:51:15Z","timestamp":1788249075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["An In\u00a0Vitro and In\u00a0Vivo Assessment of the Anti\u2010Breast Cancer Activity of\n \n Erythrina excelsa<\/i>\n <\/scp>\n Baker (Fabaceae) Bark Extracts"],"prefix":"10.1002","volume":"9","author":[{"given":"Jonas","family":"Walantini","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science University of Maroua Maroua Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2386-3020","authenticated-orcid":false,"given":"Marius Tr\u00e9sor Kemegne","family":"Sipping","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 1 Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4958-4030","authenticated-orcid":false,"given":"Merline Nguedia","family":"Ymele","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science University of Maroua Maroua Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland Nhouma","family":"Rebe","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science University of Maroua Maroua Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00ebl Abel Gbaweng","family":"Yaya","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science University of Ngaoundere Ngaoundere Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-8075","authenticated-orcid":false,"given":"Derek Tantoh","family":"Ndinteh","sequence":"additional","affiliation":[{"name":"Centre for Natural Product Research, Department of Chemical Sciences University of Johannesburg Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieudonn\u00e9","family":"Njamen","sequence":"additional","affiliation":[{"name":"Department of Animal Biology and Physiology, Faculty of Science University of Yaound\u00e9 1 Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4854-8783","authenticated-orcid":false,"given":"St\u00e9phane","family":"Zingue","sequence":"additional","affiliation":[{"name":"Centre for Natural Product Research, Department of Chemical Sciences University of Johannesburg Johannesburg South Africa"},{"name":"Department of Pharmacotoxicology and Pharmacokinetics, Faculty of Medicine and Biomedical Sciences University of Yaound\u00e9 1 Yaound\u00e9 Cameroon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.32887"},{"key":"e_1_2_13_3_1","unstructured":"C. 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