{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:48Z","timestamp":1790618208520,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hepatoid adenocarcinoma of the lung (HAL) is a rare form of lung cancer with histological and morphological properties of hepatocellular carcinoma, characterized by an aggressive course of the disease and unfavorable prognosis. Given the rarity of the pathology and the lack of unambiguous therapeutic protocols, descriptions of clinical cases of HAL deserve attention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>\n                      We describe a case of metastatic HAL in a 61\u2010year\u2010old patient, harboring a mismatch repair deficiency associated with the loss of PMS2 protein expression. Molecular\u2010genetic study identified several oncogenic variants including\n                      <jats:italic>PMS2<\/jats:italic>\n                      p.Arg421Ter,\n                      <jats:italic>PMS2<\/jats:italic>\n                      p.Arg107Trp, and\n                      <jats:italic>POLE<\/jats:italic>\n                      p.Pro286Arg and confirmed their somatic status. The laboratory findings clinically justified the use of immunotherapy with pembrolizumab, which afforded stabilization of the disease according to computed tomography data and complete tumor response according to morphological examination data.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The presented case highlights the room for immunotherapy in the highly aggressive HAL. The\n                      <jats:italic>POLE<\/jats:italic>\n                      p.Pro286Arg missense mutation has been attributed as a predictor for immune checkpoint inhibition efficacy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70661","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T08:23:31Z","timestamp":1788855811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A\n                    <scp>\n                      <i>POLE<\/i>\n                      P286R\n                    <\/scp>\n                    \u2010Mutated Hepatoid Adenocarcinoma of the Lung Showing Substantial Response to Immune Checkpoint Inhibition"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7315-0878","authenticated-orcid":false,"given":"Aleksey","family":"Chernev","sequence":"first","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7269-3948","authenticated-orcid":false,"given":"Alina","family":"Kaurtseva","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9179-8430","authenticated-orcid":false,"given":"Ruslan","family":"Abasov","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"},{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Enikeev","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Gegelia","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8989-6098","authenticated-orcid":false,"given":"Gulnara","family":"Abdrakova","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5999-8843","authenticated-orcid":false,"given":"Natalia","family":"Usman","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-8622","authenticated-orcid":false,"given":"Alexander","family":"Druy","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"},{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-6552","authenticated-orcid":false,"given":"Grigory","family":"Raskin","sequence":"additional","affiliation":[{"name":"Dr. Sergey Berezin Medical Institute  St. Petersburg Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Thoracic Tumours: WHO Classification of Tumours Series","author":"WHO Classification of Tumours Editorial Board","year":"2021"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2019.04.032"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01600112"},{"issue":"3","key":"e_1_2_11_5_1","first-page":"898","article-title":"Merged Hepatopulmonary Features in Hepatoid Adenocarcinoma of the Lung: A Systematic Review","volume":"13","author":"Mao J. 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