{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:05:58Z","timestamp":1789563958196,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T00:00:00Z","timestamp":1787443200000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Skin rash (SR) is a key issue in the long\u2010term use of apalutamide (APA) in patients with prostate cancer (PCa); however, there is currently no established strategy for the safe management of APA in preventing SR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate the predictive value of early elevation in the proportion of eosinophils (EE) for SR in patients treated with APA for PCa.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed the clinical data of 78 patients who received APA for PCa between April 2021 and November 2024. Early EE was defined as beyond the upper normal limit of 5.0% within 3\u2009months of APA treatment initiation. The initial SR (I\u2010SR) and recurrent (R\u2010) SR incidences were compared between patients with and without early EE. During a median follow\u2010up period of 14.7\u2009months, 35 patients (44.9%) developed SR, and a significantly higher proportion of patients with early EE had I\u2010SR than those without early EE (87.5% [7\/8] vs. 40.0% [28\/70];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.020). Six of the seven patients with early EE and I\u2010SR had EE before the onset of I\u2010SR (85.7%). In terms of R\u2010SR, among patients who reduced the APA dose after I\u2010SR, R\u2010SR remained significantly more prevalent in patients with early EE compared with that in patients without early EE (75.0% [3\/4] vs. 11.1% [2\/18];\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.016).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The present study suggests that early EE has predictive value for I\u2010 and R\u2010SR in patients who receive APA for PCa. Further large\u2010scale studies are warranted to verify the clinical utility of early EE in patients with APA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70662","type":"journal-article","created":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T05:03:04Z","timestamp":1787547784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Skin Rash Management Based on Early Elevation in the Eosinophil Proportion Within 3\u2009Months of Initiating Apalutamide for Prostate Cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0731-2579","authenticated-orcid":false,"given":"Dai","family":"Koguchi","sequence":"first","affiliation":[{"name":"Department of Urology Kitasato University School of Medicine  Sagamihara Kanagawa 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