{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:57Z","timestamp":1790618217540,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T00:00:00Z","timestamp":1788134400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006182","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Esp\u00edrito Santo","doi-asserted-by":"publisher","award":["2025\u20104NJHN"],"award-info":[{"award-number":["2025\u20104NJHN"]}],"id":[{"id":"10.13039\/501100006182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prostate cancer (PCa) remains one of the most frequently diagnosed malignancies worldwide and represents a major contributor to premature mortality among men. This study aimed to estimate survival and investigate factors associated with PCa\u2010specific mortality among men treated within the oncology care network of a Brazilian state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Retrospective cohort study was conducted using data obtained from hospital\u2010based cancer registries linked to the state Mortality Information System. The cohort included 10\u2009556 men diagnosed with PCa between 2000 and 2016, with follow\u2010up through 2021. Outcomes were categorized as death from PCa, death from other causes, or alive at the end of follow\u2010up. Associations with PCa\u2010specific mortality were examined using cause\u2010specific Cox proportional hazards regression models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At the end of 2021, 6388 patients were alive, 1936 had died from PCa and 2232 deaths from other causes. The 5\u2010year PCa\u2010specific survival was 87.7%. In the multivariable analysis, increasing age at diagnosis (per 10\u2010year increment) was associated with a higher cause\u2010specific hazard of PCa mortality (HR\u2009=\u20091.14; 95% CI: 1.06\u20131.22). Lower educational level was also associated with increased mortality, while patients with basic education (HR\u2009=\u20090.82; 95% CI: 0.71\u20130.95) and middle or high education (HR\u2009=\u20090.64; 95% CI: 0.52\u20130.80) showed a lower risk of death compared to those with no formal education. Referral from non\u2010SUS services was associated with a slightly higher risk of PCa mortality (HR\u2009=\u20091.14; 95% CI: 1.00\u20131.30). Regarding treatment variables, surgery was associated with a lower cause\u2010specific hazard of mortality (HR\u2009=\u20090.41; 95% CI: 0.33\u20130.52), whereas hormone therapy was associated with an increased cause\u2010specific hazard of death (HR\u2009=\u20091.98; 95% CI: 1.75\u20132.24).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Age, educational level, presence of distant metastasis, referral source, and treatment modalities were associated with PCa\u2010specific mortality. However, treatment\u2010related associations should be interpreted with caution, as they likely reflect underlying disease severity and treatment selection patterns rather than causal effects. These findings highlight the importance of early diagnosis, reducing social inequalities in access to care, and strengthening oncology care networks to improve outcomes in patients with PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70667","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T01:01:02Z","timestamp":1788224462000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Survival and Mortality Predictors in Prostate Cancer: A Retrospective Cohort of 10\u2009556 Brazilian Patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3572-6031","authenticated-orcid":false,"given":"Wesley Rocha","family":"Grippa","sequence":"first","affiliation":[{"name":"Graduate Program in Public Health, Health Sciences Center Federal University of Esp\u00edrito Santo (UFES)  Vitoria Esp\u00edrito Santo Brazil"},{"name":"Department of Applied 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