{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:03Z","timestamp":1790618223715,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007083","name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007083","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Finding reliable prognostic markers for patients with brain metastases would be beneficial since they could be used in clinical practice when making treatment decisions. Recent literature has analyzed the role of temporalis muscle thickness (TMT) as a prognostic marker in patients with brain metastases with mixed results. Previous studies have generally focused on patients younger than 65\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>The purpose of this study was to evaluate the effect of TMT measured from head CT scans on the prognosis of patients with brain metastases receiving radiotherapy aged 70\u2009years or older.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We identified all patients with brain metastases treated with radiotherapy and measured their TMT from head CT scans at the date of treatment planning CT scans. The patients' demographic data, primary tumor, and treatment allocation were recorded. Sex\u2010specific cut\u2010offs for low TMT (males: 4.3\u2009mm, females: 3.975\u2009mm) were determined by maximizing Youden's index for 3\u2010month survival. We evaluated the association between TMT and 1\u2010, 3\u2010, 6\u2010, and 12\u2010month overall survival (OS) using Cox proportional hazards modelling. This retrospective study included 249 patients. The mean age of the patients in the cohort was 76.0\u2009\u00b1\u20094.9\u2009years. Male patients had higher TMT than females (4.7\u2009\u00b1\u20091.6 vs. 3.7\u2009\u00b1\u20091.5\u2009mm,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Altogether, 35 (14.1%), 125 (50.2%), 178 (71.5%), and 216 (86.7%) patients had deceased at 1\u2010month, 3\u2010month, 6\u2010month, and 12\u2010month points, respectively. Although having low TMT was associated with a higher risk of death at 3\u2010 and 6\u2010month timepoints (hazard ratio range: 1.41\u20131.54) in univariate analyses, TMT was not associated with 3\u2010 or 6\u2010month survival after adjustment for other clinical factors.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Low TMT is not an independent marker of lower prognosis in patients aged 70\u2009years or older with brain metastases treated with radiotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70671","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:31:22Z","timestamp":1788355882000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Temporal Muscle Thickness and Survival in Older Patients With Brain Metastases Undergoing Radiation Therapy"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7992-0968","authenticated-orcid":false,"given":"Lasse","family":"Pikkarainen","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tampere University  Tampere Finland"},{"name":"Department of Radiology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5500-9200","authenticated-orcid":false,"given":"Tommi K.","family":"Korhonen","sequence":"additional","affiliation":[{"name":"Neurosurgery, OYS Neurocenter Oulu University Hospital  Oulu Finland"},{"name":"Research Unit of Clinical Neuroscience, Neurosurgery Oulu University Hospital and University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antti","family":"Tolonen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tampere University  Tampere Finland"},{"name":"Department of Radiology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8286-8274","authenticated-orcid":false,"given":"Emilia K.","family":"Pesonen","sequence":"additional","affiliation":[{"name":"Neurosurgery, OYS Neurocenter Oulu University Hospital  Oulu Finland"},{"name":"Research Unit of Clinical Neuroscience, Neurosurgery Oulu University Hospital and University of Oulu  Oulu Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9391-7157","authenticated-orcid":false,"given":"Nicole","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tampere University  Tampere Finland"},{"name":"Department of Radiology Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Skytt\u00e4","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tampere University  Tampere Finland"},{"name":"Department of Oncology, Tays Cancer Centre Tampere University Hospital  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8541-0126","authenticated-orcid":false,"given":"Otso","family":"Arponen","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences Tampere University  Tampere Finland"},{"name":"Department of Radiology Tampere University Hospital  Tampere Finland"},{"name":"Institute of Clinical Medicine, School of Medicine University of Eastern Finland  Kuopio 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