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We analyzed 116 case reports from 115 studies and highlighted the commonest irAEs, treatments instituted, and ensuing outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Myocarditis was the most common, accompanied frequently by pericarditis and heart failure. Treatment typically included corticosteroids and discontinuation of ICI therapy. Higher doses of corticosteroids appeared promising. Refractory cases benefited from plasmapheresis, intravenous immunoglobulin, mycophenolate, tacrolimus, or infliximab. Rechallenging ICI therapy after irAEs resulted in mixed outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the heterogeneity of data, analysis of aggregated data from central repositories like Side Effect Registry Immuno\u2010Oncology (SERIO) would be invaluable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70675","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T03:38:22Z","timestamp":1789702702000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Immune\u2010Related Adverse Events of Immune Checkpoint Inhibitors: A Systematic Review and Meta\u2010Summary of Case 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