{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:46Z","timestamp":1790618206377,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82573874"],"award-info":[{"award-number":["82573874"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Salivary duct carcinoma is an aggressive salivary gland malignancy in which systemic therapy is often guided by androgen receptor and HER2 status. Treatment options are limited for HER2\u2010negative disease after progression on androgen\u2010deprivation therapy and chemotherapy, particularly when active central nervous system (CNS) involvement develops.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 62\u2010year\u2010old man with androgen receptor\u2010positive, HER2\u2010negative salivary duct carcinoma developed progressive intracranial dural metastases involving the left temporal and occipital regions after surgery, adjuvant radiotherapy, androgen\u2010deprivation therapy, and multiple chemotherapy\u2010based regimens. The dominant lesion was a 33.6\u2010mm left temporal dural\u2010based mass extending across the left tentorial leaflet. Immunohistochemical profiling of archival primary tumor tissue showed high membranous TROP2 expression (H\u2010score, 230). Off\u2010label sacituzumab tirumotecan was initiated at 350\u2009mg every 2\u2009weeks without concurrent corticosteroids or local CNS\u2010directed therapy. Serial magnetic resonance imaging demonstrated sustained regression of the dominant left temporal mass from 33.6 to 15.3\u2009mm (\u221254.5%), with no new intracranial lesions. Intracranial disease control was maintained for approximately 9\u2009months. Treatment\u2010related Grade 2 oral mucositis and leukopenia improved with supportive care and did not require dose reduction or treatment discontinuation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In heavily pretreated, HER2\u2010negative salivary duct carcinoma with high TROP2 expression and progressive intracranial dural metastases, sacituzumab tirumotecan was associated with a durable intracranial response without local CNS\u2010directed therapy. This observation supports further clinical evaluation of TROP2\u2010directed antibody\u2013drug conjugates in salivary duct carcinoma with CNS involvement, while the predictive value of TROP2 expression remains to be established.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70676","type":"journal-article","created":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:51:38Z","timestamp":1790049098000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Durable Intracranial Response to Sacituzumab Tirumotecan in\n                    <scp>HER2<\/scp>\n                    \u2010Negative Salivary Duct Carcinoma With High\n                    <scp>TROP2<\/scp>\n                    Expression: A Case 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