{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:56:00Z","timestamp":1790844960316,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Over the past several decades, advances in basic and clinical research have increasingly established cancer\u2010induced cachexia as a distinct pathophysiological syndrome that warrants targeted therapeutic approaches alongside conventional anticancer treatments. Despite its high prevalence and substantial impact on morbidity, mortality, and quality of life, the condition remains underrecognized and inadequately managed in clinical practice. Correspondingly, scientific activity in the field has expanded rapidly, spanning molecular mechanisms, clinical characterization, and emerging interventional strategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This bibliometric analysis aims to provide a comprehensive, quantitative overview of evolving research in cancer\u2010induced cachexia over the past 25\u2009years. We conducted a bibliometric analysis of cancer cachexia research published between 2001 and 2025 using the Web of Science Core Collection. A total of 5775 English\u2010language primary research articles were retrieved using the search terms \u201ccancer AND cachexia,\u201d and including papers in English of the types articles, letters, and proceedings papers. Data were analyzed using the\n                      <jats:italic>Bibliometrix<\/jats:italic>\n                      R package and its web interface, BiblioShiny, to assess publication trends, author productivity, collaboration networks, and keyword co\u2010occurrence. Additional visualizations were generated using the R programming language and AI\u2010guided analyses to explore trends and bursts in the evolution of cachexia research.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cancer cachexia publications increased at an annual rate of 6.7%, exceeding the overall growth rate of scientific literature. In terms of number of papers and citation indices, the Journal of Cachexia, Sarcopenia and Muscle is the dominant journal in the field. Research is characterized by high levels of international collaboration, though research networks remain geographically clustered. Keywords were analyzed using co\u2010occurrence networks to reveal specific connections and clusters of research topics. Trend analyses of keywords showed the progression of research in the areas of metabolism and the role of inflammatory mediators. Burst analysis revealed research \u201chotspots\u201d over the last 25\u2009years including studies of specific interventions such as immunotherapy, gastrointestinal cancers, and metabolic dysregulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cancer cachexia research has expanded significantly over the past two decades but remains limited in scale and fragmented across geographic and disciplinary boundaries. A shift toward investigating biological mechanisms and therapeutics indicates a maturing field with growing translational potential. Growing trends and recent research bursts in immune function and inflammation suggest an important role of these areas in further therapeutic development. Continued integration of clinical, nutritional, and molecular research will be essential to advance effective interventions. This bibliometric analysis offers a data\u2010driven foundation to inform future research priorities and collaboration strategies in cancer\u2010induced cachexia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70690","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:04:22Z","timestamp":1790841862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Growth and Trends in Cancer\u2010Induced Cachexia Research: A Bibliometric and\n                    <scp>AI<\/scp>\n                    \u2010Guided Visualization Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-9539","authenticated-orcid":false,"given":"Thomas M.","family":"O'Connell","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Head &amp; Neck Surgery Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Indiana Center for Musculoskeletal Health Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhika","family":"Gedela","sequence":"additional","affiliation":[{"name":"Luddy School of Informatics, Computing and Engineering Indiana University Indianapolis  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3562-8629","authenticated-orcid":false,"given":"Fabrizio","family":"Pin","sequence":"additional","affiliation":[{"name":"Indiana Center for Musculoskeletal Health Indiana University School of Medicine  Indianapolis Indiana USA"},{"name":"Department of Anatomy, Cell Biology and Physiology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,1]]},"reference":[{"issue":"9","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"100282","DOI":"10.1016\/j.advnut.2024.100282","article-title":"Prevalence of and Survival With Cachexia Among Patients With Cancer: A Systematic Review and Meta\u2010Analysis","volume":"15","author":"Takaoka T.","year":"2024","journal-title":"Advances in Nutrition"},{"issue":"5","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/S1470-2045(10)70218-7","article-title":"Definition and Classification of Cancer Cachexia: An International Consensus","volume":"12","author":"Fearon K.","year":"2011","journal-title":"Lancet Oncology"},{"issue":"3","key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"101381","DOI":"10.1016\/j.jocd.2023.101381","article-title":"Bibliometric Analysis of Geriatric Sarcopenia Therapies: Highlighting Publication Trends and Leading\u2010Edge Research Directions","volume":"26","author":"Ding K.","year":"2023","journal-title":"Journal of Clinical Densitometry"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"1056732","DOI":"10.3389\/fsurg.2022.1056732","article-title":"Bibliometric Analysis of Research Trends in Relationship Between Sarcopenia and Surgery","volume":"9","author":"Liu T.","year":"2022","journal-title":"Frontiers in Surgery"},{"issue":"7","key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s00508-016-1126-2","article-title":"Publication Trends in Cachexia and Sarcopenia in Elderly Heart Failure Patients","volume":"128","author":"Springer J.","year":"2016","journal-title":"Wiener Klinische Wochenschrift"},{"issue":"14","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"8866","DOI":"10.3390\/ijerph19148866","article-title":"Bibliometric Analysis of the Knowledge Base and Future Trends on Sarcopenia From 1999\u20102021","volume":"19","author":"Xiao Y.","year":"2022","journal-title":"International Journal of Environmental Research and Public Health"},{"issue":"7","key":"e_1_2_10_8_1","first-page":"e64687","article-title":"Research Hotspots and Trends of Interventions for Sarcopenic Obesity: A Bibliometric Analysis","volume":"16","author":"Zhang N.","year":"2024","journal-title":"Cureus"},{"issue":"4","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"Bibliometrix: An R\u2010Tool for Comprehensive Science Mapping Analysis","volume":"11","author":"Aria M. 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