{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:57:30Z","timestamp":1790618250577,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Although older adults (\u2265\u200975\u2009years) constitute a large proportion of patients with unresectable pancreatic cancer (PC), they remain underrepresented in clinical trials. Biweekly gemcitabine plus nab\u2010paclitaxel (GnP) has been evaluated in retrospective studies as an alternative dosing schedule, whereas prospective evidence remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>This single\u2010center, prospective Phase II trial aimed to evaluate the efficacy and safety of biweekly GnP as a first\u2010line therapy in older adults with unresectable PC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      Eligible patients aged \u2265\u200975\u2009years with histologically or cytologically confirmed unresectable pancreatic adenocarcinoma received GnP (1000\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      gemcitabine; 125\u2009mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      nab\u2010paclitaxel) on days 1 and 15 of each 28\u2010day\u2009cycle. The primary endpoint was the overall response rate (ORR). Key secondary endpoints included overall survival (OS), progression\u2010free survival (PFS), and safety.\n                    <\/jats:p>\n                    <jats:p>A total of 17 patients were enrolled between August 2019 and March 2021 (median age, 77\u2009years; 13 metastatic, 4 locally advanced). The ORR was 47.1% (8\/17; 95% confidence interval [CI], 23.0%\u201372.2%), and the disease control rate was 82.4% (14\/17). The median OS and PFS were 16.8 (95% CI, 5.9\u201324.6) and 8.3 (95% CI, 4.9\u201310.1) months, respectively. The 1\u2010 and 2\u2010year survival rates were 58.8% and 29.4%, respectively. Grade \u2265\u20093 hematologic adverse events occurred in 17.6% of patients. Treatment\u2010related adverse events led to treatment discontinuation in three patients: one case of interstitial pneumonia and two cases of peripheral sensory neuropathy. No treatment\u2010related deaths occurred.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Biweekly GnP showed promising antitumor activity in a selected population of patients aged \u2265\u200975\u2009years with unresectable PC. Because enrollment ended before the planned sample size was reached, the study findings should be interpreted cautiously.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      jRCTs051190038\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70691","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:06:02Z","timestamp":1789430762000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prospective Phase\n                    <scp>II<\/scp>\n                    Trial of Biweekly Gemcitabine Plus Nab\u2010Paclitaxel as First\u2010Line Therapy in Patients Aged 75\u2009Years and Older With Unresectable Pancreatic Cancer"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-8960","authenticated-orcid":false,"given":"Kenji","family":"Ikezawa","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Gastroenterology and Hepatology Kansai Rosai Hospital  Amagasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Imai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic Oncology Osaka International Cancer Institute  Osaka Japan"},{"name":"Department of Gastroenterology and Hepatology Itami City Hospital  Itami Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6568-8091","authenticated-orcid":false,"given":"Ryoji","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary and Pancreatic 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