{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:57Z","timestamp":1790618217500,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:00:00Z","timestamp":1789516800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Structural incomplete response (SIR) after radioactive iodine (RAI) therapy indicates persistent or recurrent structural disease and has important implications for the long\u2010term management of patients with papillary thyroid carcinoma (PTC). However, predictors of SIR across recurrence\u2010risk strata remain incompletely characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To identify factors associated with SIR following RAI therapy in risk\u2010stratified PTC patients and to develop a predictive nomogram for intermediate\u2010risk patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 615 PTC patients who underwent thyroidectomy, lymph\u2010node dissection, and\n                      <jats:sup>131<\/jats:sup>\n                      I therapy. Patients were re\u2010stratified according to the 2025 American Thyroid Association recurrence\u2010risk framework into a low\/low\u2010to\u2010intermediate\u2010risk group and an intermediate\u2010high\/high\u2010risk group. In 396 intermediate\u2010risk patients with lymph\u2010node metastasis, univariable and multivariable logistic regression analyses were used to identify independent predictors of SIR, and a nomogram was developed and internally validated. SIR rates differed significantly between risk groups (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). Stimulated thyroglobulin (sTg) independently predicted SIR across all risk strata. The number of lymph\u2010node metastases (LNM) and lymph\u2010node yield additionally predicted SIR in intermediate\u2010high\/high\u2010risk patients. In intermediate\u2010risk patients, age, tumor size, lymph\u2010node ratio, sTg, and LNM were independent predictors of SIR. The nomogram yielded an area under the curve of 0.865 (95% CI, 0.814\u20130.916) in the training cohort and 0.733 (95% CI, 0.617\u20130.849) in the internal hold\u2010out validation cohort; the bootstrap optimism\u2010corrected area under the curve was 0.853, and the optimism\u2010corrected calibration slope was 0.92.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>sTg and LNM are key predictors of SIR in risk\u2010stratified PTC patients. In this single\u2010center retrospective cohort, the nomogram showed good discrimination and calibration for SIR in intermediate\u2010risk patients; external multicenter validation is warranted before clinical application.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70692","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T23:04:51Z","timestamp":1789599891000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognostic Factor Analysis for Risk\u2010Stratified Papillary Thyroid Carcinoma and Nomogram Development for Predicting Structural Incomplete Response to Radioactive Iodine Therapy in Intermediate\u2010Risk Patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8494-3771","authenticated-orcid":false,"given":"Yamin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaohui","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5305-2494","authenticated-orcid":false,"given":"Bin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00035-3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2018.8270"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019795"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2111953"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10507256251363120"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.2331"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m441"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/M14\u20100697"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2008.08.035"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12957\u2010018\u20101336\u20103"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020\u2010022\u201003173\u2010x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0199"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.1015798"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015\u20104016"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11223621"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2006.08.010"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.133.3.288"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0102"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2023.106563"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0460"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006\u20102707"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209288"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3431"}],"container-title":["Cancer Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70692","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cnr2.70692","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cnr2.70692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:06:46Z","timestamp":1790615206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cnr2.70692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["10.1002\/cnr2.70692"],"URL":"https:\/\/doi.org\/10.1002\/cnr2.70692","archive":["Portico"],"relation":{},"ISSN":["2573-8348","2573-8348"],"issn-type":[{"value":"2573-8348","type":"print"},{"value":"2573-8348","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70692"}}