{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:56:57Z","timestamp":1790618217632,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Tumor and liver\u2010related factors are well\u2010known prognostic factors for patients with hepatocellular carcinoma (HCC). The Japanese Society of Hepatology (JSH) guidelines recommend considering liver resection (LR) for patients with multiple tumors and a tumor number \u2264\u20093. A previous Italian study showed that a model for end\u2010stage liver disease (MELD) score of &gt;\u20099 indicates inadequate liver function reserve in patients with HCC undergoing LR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>We used these two parameters to predict the overall survival (OS) of patients with Barcelona clinic liver cancer (BCLC) Stage B HCC who underwent LR or transcatheter arterial chemoembolization (TACE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>\n                      We consecutively enrolled patients with BCLC stage B HCC and Child\u2013Pugh Class A liver disease underwent LR or TACE. Of these patients, 163 underwent LR and 270 underwent TACE. We used two parameters, that is, \u2264\u20093 nodules and a MELD score of \u2264\u20099, to subclassify BCLC stage B HCC patients. BCLC B1 had to occur concomitantly with two parameters, whereas for BCLC B2, meeting only one criterion was sufficient. The five\u2010year OS of BCLC B1 patients undergoing LR was 60% and those undergoing TACE was 37% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). The 5\u2010year OS of BCLC B2 patients undergoing LR was 23% and those undergoing TACE was 18% (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.223).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>We recommend considering LR for BCLC B1 patients, whereas TACE could be considered for BCLC B2 patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70697","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T03:52:53Z","timestamp":1789962773000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tumor Number and Model for End\u2010Stage Liver Disease Score as Selection Criteria for Resection or Embolization of Intermediate\u2010Stage Hepatocellular Carcinoma"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6251-7230","authenticated-orcid":false,"given":"Yi\u2010Hao","family":"Yen","sequence":"first","affiliation":[{"name":"Division of Hepatogastroenterology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee\u2010Chien","family":"Yong","sequence":"additional","affiliation":[{"name":"Department of Surgery, Liver Transplantation Center Kaohsiung Chang Gung Memorial Hospital  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-9131","authenticated-orcid":false,"given":"Yueh\u2010Wei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Liver Transplantation Center Kaohsiung Chang Gung Memorial Hospital  Kaohsiung 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