{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:52:22Z","timestamp":1791255142822,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:00:00Z","timestamp":1791158400000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This umbrella review aimed to systematically synthesize and critically appraise the available evidence from systematic reviews and meta\u2010analyses evaluating the association between talc exposure and cancer risk in humans.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This umbrella review was conducted in accordance with the PRIOR guidelines and registered in PROSPERO. A comprehensive search of PubMed, Embase, Scopus, Web of Science, and Epistemonikos was performed up to October 2024 without language or date restrictions. Eligible studies were systematic reviews evaluating any type of talc exposure in humans. Study selection and data extraction were performed independently, and risk of bias was assessed using the AMSTAR\u20102 tool.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Nine systematic reviews were included, eight combining cohort and case\u2013control studies and one restricted to cohort studies. Cosmetic talc exposure was the most frequently investigated, with most reviews focused on ovarian cancer. Moderate overlap of study populations (9.2%) was identified, primarily related to Boon et\u00a0al. Based on AMSTAR\u20102, confidence in the evidence was moderate in one review and critically low in seven, with frequent methodological shortcomings such as lack of protocol registration and unclear study exclusions. For occupational exposure, elevated risks were observed for overall cancer (RR 1.21; 95% CI 1.03\u20131.42) and colorectal cancer (SIR 1.59; 95% CI 1.07\u20132.26), while no increased risk was found for other cancer types. Four of five systematic reviews evaluating cosmetic talc exposure and ovarian cancer reported a statistically significant association with increased ovarian cancer risk, whereas one review found no statistically significant association. However, confidence in the results of the reviews included was predominantly low or critically low, reflecting important methodological limitations, including concerns regarding risk\u2010of\u2010bias assessment and reporting. Overall, the evidence supporting an association between cosmetic talc exposure and ovarian cancer was of limited confidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is limited evidence from systematic reviews regarding the association of exposure to cosmetic talc with an increased risk of developing ovarian cancer. Therefore, the results of the systematic reviews should be regarded as suggestive, rather than definitive, and further studies are required to demonstrate a causal relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70705","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:10:50Z","timestamp":1791252650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Talc Use and Risk of Cancer: An Umbrella Review and Overlapped Analysis"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0024","authenticated-orcid":false,"given":"Frank","family":"Mayta\u2010Tovalino","sequence":"first","affiliation":[{"name":"Vicerrectorado de Investigaci\u00f3n Universidad San Ignacio de Loyola  Lima 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Efectividad Cl\u00ednica y Sanitaria Universidad Cient\u00edfica del Sur  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-4003","authenticated-orcid":false,"given":"Adrian V.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Vicerrectorado de Investigaci\u00f3n Universidad San Ignacio de Loyola  Lima Peru"},{"name":"Health Outcomes, Policy and Evidence Synthesis (HOPES) Group University of Connecticut School of Pharmacy  Storrs Connecticut 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