{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T13:49:08Z","timestamp":1791553748214,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Reports"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Myelodysplastic syndromes (MDS) are a group of clonal hematopoietic stem cell disorders with a risk of progression to acute myeloid leukemia (AML). MDS\u2010transformed AML (MDS\u2010AML) has a poor prognosis. The concurrent presence of DEK::CAN fusion gene positivity and WT1 overexpression is extremely rare and likely denotes a highly aggressive disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 57\u2010year\u2010old Han Chinese female with a 5\u2010year history of MDS (DEK::CAN status at initial diagnosis unknown) presented with fatigue and pancytopenia. Bone marrow blasts accounted for 81% (AML\u2010M5), and karyotype showed t(6;9)(p23;q34). Real\u2010time quantitative PCR (qPCR) revealed a DEK::CAN\/ABL ratio of 188.21% and a WT1\/ABL ratio of 52.90%; next\u2010generation sequencing identified a U2AF1 mutation (p.Arg156His). The patient received IA regimen induction followed by intermediate\u2010dose cytarabine consolidation. Complete remission (CR) was achieved after induction; after the first consolidation cycle, a transient CR with incomplete hematologic recovery (CRi) occurred, and CR was re\u2010established at the final evaluation. Severe infections occurred repeatedly during treatment. Although the patient achieved CR after induction chemotherapy, recurrent infections and cumulative chemotherapy\u2010related cytopenias prevented timely allogeneic hematopoietic stem cell transplantation (allo\u2010HSCT). She died approximately 1\u2009month after the last chemotherapy cycle; the cause was clinically suspected to be fatal hemorrhage, though autopsy was not performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MDS\u2010AML with concurrent DEK::CAN and WT1 mRNA overexpression is a highly aggressive entity. Although chemotherapy can induce remission, treatment\u2010related complications often preclude transplantation. Early molecular screening is recommended, and once any form of remission (CR or CRi) is achieved, prompt bridging to allo\u2010HSCT should be pursued. Targeted therapy should also be explored.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70714","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:53:02Z","timestamp":1791550382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Myelodysplastic Syndromes\u2010Transformed Acute Myeloid Leukemia With Concurrent\n                    <scp>DEK<\/scp>\n                    ::\n                    <scp>CAN<\/scp>\n                    Fusion Gene Positivity and\n                    <scp>WT1<\/scp>\n                    Overexpression: A Case Report and Literature Review"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-6777-6393","authenticated-orcid":false,"given":"Wanxiu","family":"Mao","sequence":"first","affiliation":[{"name":"Zhejiang Chinese Medical University  Hangzhou China"},{"name":"Department of Hematology, Wenzhou Key Laboratory of Hematology Research The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengmin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wenzhou Key Laboratory of Hematology Research The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wenzhou Key Laboratory of Hematology Research The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2039-4233","authenticated-orcid":false,"given":"Songfu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wenzhou Key Laboratory of Hematology Research The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3442-4066","authenticated-orcid":false,"given":"Zhijie","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Wenzhou Key Laboratory of Hematology Research The First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.14578"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cll.2023.07.001"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-021-00741-w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.208678"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-13-440"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2021.1951938"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2021.106727"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-025-01769-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2019.65.7.24"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12641"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123306"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060699"},{"key":"e_1_2_11_14_1","first-page":"171","volume-title":"Guidelines of Chinese Society of Clinical Oncology (CSCO) Hematological Malignancies 2020","author":"Chinese Society of Clinical Oncology Committee on Guidelines for Cancer and Cancer\u2010Related Guidelines","year":"2020"},{"issue":"7","key":"e_1_2_11_15_1","first-page":"491","article-title":"Intensive Pretreatment Protocol Allogeneic Hematopoietic Stem Cell Transplantation to Overcome Poor Prognosis in Patients With t (6; 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