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There is a growing need for accessible, minimally invasive molecular biomarkers that complement current diagnostic approaches and support molecular subtype classification.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>\n                      This exploratory case\u2013control study evaluated the plasma expression of four circulating miRNAs (miR\u201021\u20105p, miR\u2010486\u20103p, miR\u2010451a, and miR\u2010660\u20105p) in\u00a0Peruvian women with Luminal A (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200932) and Luminal B (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200943) breast cancer and healthy controls (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200936).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods\u00a0and\u00a0Results<\/jats:title>\n                    <jats:p>\n                      Expression levels were quantified by qPCR, and diagnostic performance was assessed using logistic\u00a0regression with leave\u2010one\u2010out cross\u2010validation (LOOCV). miR\u2010486\u20103p was significantly upregulated in Luminal A\u00a0compared with both controls and Luminal B, whereas miR\u201021\u20105p was downregulated relative to controls. After validation, miR\u2010486\u20103p retained moderate discriminative ability for distinguishing Luminal A from controls (AUC\u2009=\u20090.651; 95% CI: 0.461\u20130.841;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.120), while the combined miR\u2010486\u20103p\/miR\u201021\u20105p model showed moderate discriminatory performance for\u00a0differentiating Luminal A from Luminal B (AUC\u2009=\u20090.690; 95% CI: 0.466\u20130.914;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0959). Exploratory functional enrichment analyses\u00a0suggested that experimentally validated targets of these miRNAs were associated with cancer\u2010 and immune\u2010related pathways, providing biological context for their potential roles in breast cancer.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings\u00a0provide\u00a0preliminary evidence supporting the potential of circulating miR\u2010486\u20103p and miR\u201021\u20105p as candidate non\u2010invasive biomarkers for future early detection and molecular subtype classification of Luminal breast cancer. However, these findings should be interpreted cautiously and require validation in larger, independent cohorts before clinical implementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cnr2.70717","type":"journal-article","created":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T03:25:56Z","timestamp":1791602756000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploratory Analysis of Circulating\n                    <scp>miR<\/scp>\n                    \u2010486\u20103p and\n                    <scp>miR<\/scp>\n                    \u201021\u20105p in Early Detection and Subtype Classification of\u00a0Luminal A and B Breast Cancer in Peruvian Women"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4727-9179","authenticated-orcid":false,"given":"Desire\u00e9","family":"Bouroncle","sequence":"first","affiliation":[{"name":"Genomics and Integrative Biology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0472-3612","authenticated-orcid":false,"given":"Gustavo","family":"Colque","sequence":"additional","affiliation":[{"name":"Genomics and Integrative Biology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3735-2372","authenticated-orcid":false,"given":"Luis","family":"Huaytalla\u2010Bautista","sequence":"additional","affiliation":[{"name":"Genomics and Integrative Biology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2812-7732","authenticated-orcid":false,"given":"Mar\u00eda Claudia","family":"Flores\u2010Berrospi","sequence":"additional","affiliation":[{"name":"Genomics and Integrative Biology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-7340","authenticated-orcid":false,"given":"Carla","family":"Bernal","sequence":"additional","affiliation":[{"name":"Genomics and Integrative Biology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos  Lima Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4465-5650","authenticated-orcid":false,"given":"Ivan","family":"Belzusarri","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Instituto Nacional de Enfermedades Neoplasicas  Lima 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